Clinical Development Leader, Lifecycle Management

Scorpion Therapeutics; Boston (MA); On-site; USD 280,000 - 350,000; Full time

Benefits offered by this job

Long-term stock incentives

ESPP

Discretionary quarterly bonus

Wellness benefit

Generous PTO

Paid holidays and company-wideShutdown

Job summary

Scorpion Therapeutics is seeking a senior clinical development leader to drive late-stage programs and IND-enabling submissions. You will guide global teams across development, regulatory, safety, and translational sciences, shaping strategies from discovery through human trials.

The role demands a proven track record in leading clinical programs, strong regulatory interactions, and the ability to thrive in a dynamic environment with shifting priorities.

Qualifications

• Advanced scientific degree required (MD/PhD/PharmD or equivalent).
• Experience leading clinical trials, programs, submissions, or major development decisions.
• Regulatory submission ownership for IND/CTA/NDA/MAA filings and health authority interactions.
• Strong judgment to make timely calls with incomplete information.
• Comfort in a dynamic environment with shifting priorities.

Responsibilities

• Develop lifecycle strategy to expand late-stage assets and marketed indications.
• Lead first-in-human and dose-escalation studies using PK/PD and emerging data.
• Drive clinical strategy for IND-enabling submissions and human studies.
• Provide pipeline-wide leadership across mechanisms, indications and phases.
• Interpret emerging data and make timely data-driven decisions.
• Lead cross-functional teams and engage investigators, KOLs, health authorities, and partners.

Skills

Clinical development leadership

Data-driven decision making

Cross-functional leadership

Regulatory interactions

Education

MD/PhD/PharmD

Job description

Primary Responsibilities

• Lifecycle strategy: Identify and drive opportunities to expand the impact of late-stage and marketed assets, including new indications, label expansion, and formulation opportunities.
• Early development: Lead first-in-human and dose-escalation studies, applying PK/PD and emerging clinical data to dose selection, decision rules, and next-stage development.
• Clinical entry: Drive the clinical strategy and content for IND-enabling submissions and the decisions required to move programs into human studies.
• Pipeline-wide leadership: Work across mechanisms, indications, and phases to make sound clinical development decisions.
• Data-driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
• Cross-functional and external leadership: Lead teams across clinical operations, biostatistics, regulatory, safety, translational sciences, and other disciplines; represent the company with investigators, KOLs, health authorities, and partners.

Qualifications

• Advanced scientific degree (MD, PharmD, PhD, or equivalent) required.
• Track record of clinical trials, programs, submissions, or major development decisions personally led.
• Regulatory submission ownership: clinical content of IND/CTA/NDA/MAA filings, briefing books, and health authority interactions.
• Strong judgment to make timely calls on emerging data with incomplete information; ability to know what to escal
• Comfort in a dynamic environment with shifting priorities and evolving scope.

Benefits

• Annualized base salary: $280,000–$350,000 USD.
• Benefits include 99% premium paid for medical/dental/vision; company-paid life insurance, AD&D, disability; voluntary plans; 401(k) match up to 6%; long-term stock incentives and ESPP; discretionary quarterly bonus; wellness benefit; generous PTO; paid holidays and company-wide shutdowns.