Chief Radiochemistry & Isotope Production Lead

Subcritical Systems; Austin (TX); On-site; USD 210,000 - 310,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

Job summary

Subcritical Systems, Inc. in Austin, Texas, is seeking a leader to develop and operate its accelerator-based radioisotope production program.

You will build radiochemistry capabilities, define GMP-compliant processing, and align production with clinical and industrial demand across North America, Europe, and Asia. Responsibilities include establishing target development, irradiation workflows, radiochemical processing, QC, and regulatory readiness, while building a multidisciplinary team to

Qualifications

• PhD or advanced degree in relevant radiochemistry or nuclear engineering.
• 8+ years in radioisotope production or accelerator-based nuclear science.
• Experience leading isotope production programs in accelerator, lab, or radiopharmaceutical setting.
• Hands-on experience with radiochemical separations in hot cells.
• Strong knowledge of radionuclide production pathways, decay, and GMP workflows.

Responsibilities

• Lead development and operation of proton accelerator-based radioisotope production.
• Define isotope production roadmap based on feasibility, market demand, radiopharmaceutical pipelines, and clinical requirements.
• Develop irradiation, target handling, radiochemical processing, purification, and recovery workflows.
• Lead design, installation, commissioning, and qualification of hot cells and isotope-processing infrastructure.
• Design and implement GMP-quality chemical separation and purification processes for radioactive materials.
• Establish robust production workflows covering target receipt, irradiation, transfer, dissolution, separation, purification, QC, and waste handling.
• Partner with accelerator physics and engineering teams to optimize beam energy, current, irradiation conditions, target design, cooling, and isotope yield.
• Develop and maintain isotope production models incorporating reaction cross-sections, yield, and timelines.
• Establish quality systems, batch documentation, analytical methods, specifications, and release criteria for radiopharmaceuticals.
• Ensure radiochemistry operations comply with radiation safety and regulatory requirements.
• Build and lead a multidisciplinary team spanning radiochemistry, isotope production, analytical chemistry, and operations.
• Stay aligned with radiopharmaceutical clinical programs and translate isotope demand into production capacity planning.

Education

PhD or advanced degree in Radiochemistry, Nuclear Chemistry, Chemistry, Chemical Engineering, Nuclear Engineering, or a closely related discipline

Tools

Hot cells experience

Radiochemical processing equipment

GMP facilities

Job description

Subcritical Systems, Inc. in Austin, Texas, is seeking a leader to develop and operate its accelerator-based radioisotope production program.

You will build radiochemistry capabilities, define GMP-compliant processing, and align production with clinical and industrial demand across North America, Europe, and Asia. Responsibilities include establishing target development, irradiation workflows, radiochemical processing, QC, and regulatory readiness, while building a multidisciplinary team to