Cell Line Development Scientist (CHO) – End-to-End GMP role

AbbVie; South San Francisco (CA); On-site; USD 110,000 - 140,000; Full time

Job summary

AbbVie in South San Francisco, CA, is seeking a Scientist I to join the Cell Line Development group. You will execute CHO cell line development and characterization studies for GMP applications, supporting the biologics pipeline from bench to early-stage clinical work.

This hands-on role involves transfection, screening, culture scale-up, and close collaboration with process and analytical development teams.

Qualifications

• Bachelor's degree or higher in biology with lab-based experience.
• Hands-on aseptic technique and mammalian cell culture experience; CHO preferred.
• Experience with transfection and clone screening workflows.
• Proficiency in nucleic acid analysis (qPCR/ddPCR) and sequencing-based methods.
• Ability to design and interpret experiments independently and troubleshoot.

Responsibilities

• Design and interpret experiments; generate reliable results.
• Execute CHO cell line development workflows including transfection and clone screening.
• Perform molecular characterization using PCR/qPCR/ddPCR.
• Establish monoclonal CHO lines and maintain cell banks.
• Design fed-batch and parallel culture studies; assess productivity and stability.
• Maintain meticulous ELN documentation and collaborate across teams.

Skills

CHO Cell Development

Mammalian Cell Culture

Transfection

Clone Screening

qPCR/ddPCR

Education

Bachelor's degree in Biology or related field

Master's degree or equivalent in biologics

Tools

Vi-CELL

qPCR instrumentation

ddPCR instrumentation

Job description

AbbVie in South San Francisco, CA, is seeking a Scientist I to join the Cell Line Development group. You will execute CHO cell line development and characterization studies for GMP applications, supporting the biologics pipeline from bench to early-stage clinical work.

This hands-on role involves transfection, screening, culture scale-up, and close collaboration with process and analytical development teams.