Brain Health Scientist - Single-Cell Genomics (ALS)

Allen Institute; Seattle (WA); On-site; USD 86,000 - 107,000; Full time

Benefits offered by this job

Relocation assistance

Work visa sponsorship

Job summary

Allen Institute is seeking a Scientist I in Seattle to establish and optimize single cell long-read sequencing methods, validate molecular assays, and execute experiments to validate computational findings. You will collaborate with neuropathology, spatial transcriptomics, and computational teams to advance high-resolution molecular atlases of the nervous system in health and disease.

The ideal candidate has a strong foundation in molecular neuroscience and experience with single cell

Qualifications

• PhD degree in Neuroscience, Molecular Biology, Genomics, or related field, or equivalent combination of degree and experience.
• Demonstrated experience conducting independent experimental research and interpreting complex biological data.
• Broad knowledge of and experience with single cell genomics platforms.

Responsibilities

• Contribute to the design and execution of large-scale single cell genomics experiments
• Lead the development and testing of new long-read sequencing methods and protocols
• Optimize protocols for challenging samples, troubleshoot workflows for variable tissue quality, and evaluate tissue and sequencing library quality using standard metrics
• Conduct basic analysis of single cell and long-read genomics data, including benchmarking of new methods
• Present progress in group meetings and at scientific conferences, and contribute to peer-reviewed publications
• Assist in management of tissue acquisition and sample tracking
• Maintain meticulous experimental records to ensure reproducibility across tissue donors and adherence to best practices for tissue handling, biosafety, and data integrity
• Actively contribute to a collaborative environment focused on scientific rigor and methodological innovation

Skills

Single cell genomics

Python and R for data analysis

Communication skills

Team collaboration

Education

PhD in Neuroscience, Molecular Biology, Genomics

Tools

PacBio HiFi

Oxford Nanopore

Immunostaining

Job description

Allen Institute is seeking a Scientist I in Seattle to establish and optimize single cell long-read sequencing methods, validate molecular assays, and execute experiments to validate computational findings. You will collaborate with neuropathology, spatial transcriptomics, and computational teams to advance high-resolution molecular atlases of the nervous system in health and disease.

The ideal candidate has a strong foundation in molecular neuroscience and experience with single cell