Biotech Downstream Process Engineer II: Purification & Scale-Up

Takeda; Lexington (MA); On-site; USD 71,800 - 112,860; Full time

Job summary

Takeda is seeking an early-career Downstream Process Development Engineer II in Lexington, MA. You will support downstream biotherapeutics process development across micro to pilot scales, executing purification experiments and maintaining meticulous records.

You will collaborate with more senior engineers, perform data analysis, and contribute to the development and optimization of downstream processes while following established procedures and safety standards.

Qualifications

• Associate or bachelor degree with relevant experience in chemical engineering, chemistry, biochemistry, biotechnology, or related field.
• Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps.
• Comfort with emerging digital tools and AI-enabled processes for data analysis, documentation, and workflow improvement.
• Experience with basic bioprocess control systems.
• Experience using electronic laboratory notebooks for study documentation/data entry.
• Ability to perform basic data analysis and present results clearly in written form.
• Familiarity with technical writing for laboratory reports or development documents.
• Understanding of laboratory practices, process development methods, and quality requirements.
• Ability to follow detailed procedures, maintain accurate records, and work under close supervision.
• Some relevant experience in process development, protein purification, or related laboratory setting.

Responsibilities

• Execute chromatography, harvest operations, UF/DF, and viral clearance experiments.
• Support downstream process development across micro, bench, and pilot scales.
• Maintain laboratory equipment and ensure instrument readiness.
• Collaborate with senior engineers to plan and execute larger studies.
• Document experimental work in electronic lab notebooks with clear records.
• Perform basic data analysis to review trends and compare conditions.
• Prepare technical summaries, study updates, and other written materials.
• Follow laboratory and process development procedures, including quality requirements.
• Identify ways to improve workflows, data capture, and execution.
• Assist with small projects under close supervision.

Skills

Chromatography

Harvest operations

Ultrafiltration & diafiltration

Viral clearance

Data analysis

Electronic lab notebooks

Technical writing

Bioprocess knowledge

Education

Associate/Bachelor degree in relevant field

Tools

Electronic lab notebooks (ELN)

Process development software

Job description

Takeda is seeking an early-career Downstream Process Development Engineer II in Lexington, MA. You will support downstream biotherapeutics process development across micro to pilot scales, executing purification experiments and maintaining meticulous records.

You will collaborate with more senior engineers, perform data analysis, and contribute to the development and optimization of downstream processes while following established procedures and safety standards.