Bioprocess Engineer II: Fermentation & Downstream Scale-Up

Dakota BioWorx; Brookings, Northern (SD, KY); Hybrid; USD 85,000 - 120,000; Full time

Job summary

Dakota BioWorx in Brookings, SD seeks a bioprocess engineer to lead client fermentation and downstream operations. You will operate bioreactors, centrifuges, and filtration systems, while applying process data to improve yield and scale-up performance.

The role requires hands-on processing experience, strong communication, and the ability to troubleshoot and document procedures for clients and colleagues.

Qualifications

• Bachelor's degree in chemical/biochemical/biological engineering or related field.
• Over two years of bioprocessing/fermentation/process development experience with equipment handling.
• Hands-on bioreactor operation including microbial cultivation and aseptic technique.
• Experience with at least one downstream operation (centrifugation, filtration, drying).
• Apply engineering fundamentals to scale-up and process performance.
• Strong problem-solving and data interpretation with documentation.
• Clear technical communication and organized project work.

Responsibilities

• Plan and execute client fermentation and downstream work, coordinating equipment, materials, staffing needs, and timelines with the team.
• Review client processes, identify operating constraints, and develop run plans and protocols with clients and colleagues.
• Set up, operate, monitor, and clean bioreactors, centrifuges, filtration systems, homogenizers, and spray dryers within your demonstrated proficiency.
• Apply engineering calculations and data to select operating conditions and improve yield and reproducibility.
• Investigate deviations and equipment problems, identify causes, and implement corrective actions.
• Assess equipment readiness and perform routine checks and maintenance; coordinate repairs with specialists.
• Write and improve procedures, batch records, and protocols; prepare client reports and recommendations.
• Train junior scientists, engineers, and operators in equipment use and documentation practices.
• Communicate progress and risks, and follow safety procedures for biological materials and equipment.

Skills

Bioprocessing

Fermentation

Aseptic technique

Process development

Scale-up

Data interpretation

Documentation

Education

Bachelor's degree in chemical/biochemical/biological engineering

Tools

Spreadsheet software

Job description

Dakota BioWorx in Brookings, SD seeks a bioprocess engineer to lead client fermentation and downstream operations. You will operate bioreactors, centrifuges, and filtration systems, while applying process data to improve yield and scale-up performance.

The role requires hands-on processing experience, strong communication, and the ability to troubleshoot and document procedures for clients and colleagues.