Bioprocess Engineer, Cell Production & Process Development

United Therapeutics Corporation

Manchester (NH)

On-site

USD 90,000 - 130,000

Full time

14 days+

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Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401k plan

ESPP

Paid time off

Parental leave

Disability benefits

Job summary

United Therapeutics Corporation in Manchester, NH is seeking a Bioprocess Engineer to develop and scale iPS-derived autologous cells for 3D printed organs in a GMP setting. You will contribute to R&D cell production and collaborate across Organ Manufacturing to enable tissue engineering applications.

The role requires experience with iPSC culture, bioreactor systems, and automated cell processing equipment, with flexibility for a non-traditional schedule and a focus on scalable, robust processes.

Qualifications

Bachelor’s degree in biomedical science, cell biology or related field with 2+ years of industry experience or Master’s with 1+ year experience in iPSC culture and bioreactor production.
Experience with cell bioreactor culture, preferably Ambr/B-DCU systems and/or vertical wheel bioreactors up to 10L+.
Experience with automated cell processing equipment (CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea or similar).
Knowledge in transferring R&D cell expansion methods to GMP.
Proficiency with standard software and lab data tools; able to handle lab instrumentation and data software.
Ability to accommodate a non-traditional work schedule (e.g., Sun-Thu, Tue-Sat).

Responsibilities

Contribute to production to supply cells for R&D cellularization and tissue engineering of 3D printed scaffolds.
Scale-up iPSC differentiation to multiple cell types and develop robust cGMP processes.
Assist in developing, writing and reviewing lab methods and protocols.
Evaluate new technologies for future process development.
Support tech transfer from external collaborators to internal labs and to cGMP sites as needed.
Assist in evaluating lab equipment and collaborating with other Organ Manufacturing sub-groups.
Prepare data for publications and presentations; perform other duties as assigned.

Skills

Bioprocess knowledge

iPSC culture

Bioreactor operation

Automated cell processing

GMP transfer

Data/software literacy

Non-traditional schedule

Education

Bachelor's degree in biomedical science/cell biology or related field

Master's degree in biomedical science (preferred)

Tools

Sartorius Ambr/B-DCU systems

Vertical wheel bioreactors

CliniMACS Plus/LOVO/Cue/Sepax/Sefia/Rotea

Job description

California, US residents click here.

The job details are as follows:

Who We Are

We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation. Our public benefit purpose is to provide a brighter future for patients through the development of novel pharmaceutical therapies; and technologies that expand the availability of transplantable organs.

United Therapeutics (Nasdaq: UTHR) seeks to travel down the corridors of indifference to develop treatments for rare, deadly diseases. We were founded in 1996 by a family seeking a cure for their daughter's pulmonary arterial hypertension (PAH). Today, we have six FDA-approved therapies that treat PAH, pulmonary hypertension associated with interstitial lung disease (PH-ILD) and neuroblastoma, a rare pediatric cancer. Our near-term pipeline seeks to develop additional therapies for PAH and pulmonary fibrosis (PF).

The cure for end-stage life-threatening diseases like PAH, PH-ILD, PF, and many others is an organ transplant, but only a small percentage of donated organs are available to address the vast need. For this reason, we are working to create manufactured organs to address the shortage of kidneys, hearts, lungs, and livers available for transplant. We believe an unlimited supply of tolerable, transplantable organs will eliminate the transplant waiting list and cure end-stage organ diseases for which transplant is not currently an option.

Who You Are

Imagine telling people your work helps create the building blocks for 3D printed organs. At United Therapeutics, that's not science fiction. It's the mission. We're seeking a driven Bioprocess Engineer to help develop and scale robust cell production processes that support some of the most ambitious advances in regenerative medicine today. You'll join a highly collaborative team where innovation is expected, scientific curiosity is celebrated, and your contributions have the potential to change the future of transplant medicine for patients around the world.

The Bioprocess Engineer, Cell Production and Process Development (OMG) will be responsible for the execution of studies related to the scale up and process development of robust methods to produce iPS-derived autologous cells for 3D printed organs in a GMP setting. Additionally, this role will contribute to supplying primary and iPSC-derived cells for R&D tissue engineering efforts.

Contribute to the production effort to provide sufficient cells for R&D cellularization and tissue engineering efforts of 3D printed scaffolds
Execute process development studies to scale-up iPSC differentiation processes to multiple cell types and develop robust, cGMP manufacturing processes
Assist in developing, writing, and reviewing laboratory methods and protocols
Assist in evaluating new technologies for future process development
Support tech transfer activities from outside collaborators to internal laboratory and from internal PD efforts to cGMP manufacturing sites, as needed
Support the evaluation of laboratory equipment
Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization), as needed
Support the creation of data for scientific publications and presentations at scientific conferences
Perform other duties as assigned

Minimum Requirements

Bachelor's degree in biomedical science, cell biology or related field with 2+ years of relevant industry experience with prior experience in iPSC culture and bioreactor cell production or Master's degree with 1+ years of relevant industry experience with prior experience in iPSC culture and bioreactor cell production
Experience with cell bioreactor culture, preferably Sartorius Ambr/B-DCU systems and/or vertical wheel bioreactors with scales up to 10L+
Experience with automated cell processing equipment such as CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea or others
Knowledge in transfer of R&D cell expansion methods to GMP
Proficient with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
Ability to accommodate a non-traditional work schedule (e.g. Sun-Thu, Tue-Sat)

Preferred Qualifications

Master's Degree in biomedical science, cell biology or related field
Strong working knowledge of cellular process development

Job Location

This position is located in our Manchester, NH Lab. Flexible hours are necessary.

Eligible employees may participate in the Company's comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more.