Bioprocess Development Engineer - Hands-On Cell Culture

RXinsider LTD.; Plainville, Northern (MA, KY); Hybrid; USD 96,000 - 130,000; Full time

Benefits offered by this job

Healthcare

401(k) plan

Paid time off

Paid holidays

Parental leave

Employee stock purchase plan (ESPP)

Commuter benefits

Job summary

Thermo Fisher Scientific in Massachusetts is seeking a hands‑on Bioprocess Development Scientist/Engineer III to advance cell culture and analytical workflows within the Bioprocess Design Center. You will design experiments, troubleshoot bioreactors, analyze data, and translate results into scalable processes.

The role involves collaboration across upstream, downstream, analytics, automation, R&D, and customer programs, with a focus on scalable, validated workflows and cross‑functional

Qualifications

• Hands‑on experience with mammalian cell culture and bioreactor operations, preferably using CHO or other industrially relevant cell lines.
• Understanding of upstream process‑development fundamentals including media/feed strategies, process parameters, cell culture performance, and scale‑up principles.
• Practical experience with analytical techniques used in bioprocess development, such as cell counting, metabolite analysis, protein quantification, chromatography, electrophoresis, or related methods.
• Demonstrated ability to independently plan and execute experiments, analyze data, troubleshoot technical issues, and communicate technical conclusions.
• Strong written and verbal communication skills with the ability to work effectively in a multidisciplinary environment.

Responsibilities

• Design and execute mammalian cell culture studies across shake flask, bench-scale, and single‑use bioreactor systems.
• Support media and feed screening, process optimization, scale‑up/scale‑down, and technology evaluation studies.
• Operate and troubleshoot bioreactor systems and evaluate key process parameters including viable cell density, viability, metabolites, productivity, pH, dissolved oxygen, and other process indicators.
• Apply structured experimental approaches, including Design of Experiments (DoE) where appropriate, to understand relationships between process parameters and performance.
• Analyze experimental data, troubleshoot process performance, and recommend appropriate next steps.
• Execute analytical workflows supporting bioprocess development, including measurements of cell growth, metabolites, product concentration, product quality, and overall process performance.
• Operate and troubleshoot relevant analytical instrumentation and ensure generation of reliable, reproducible experimental data.
• Integrate process and analytical datasets to identify trends, investigate performance, and support process‑development decisions.
• Support development and standardization of fit‑for‑purpose analytical methods and workflows.
• Evaluate new analytical technologies and tools that improve process monitoring, characterization, and data‑driven decision‑making.

Skills

Mammalian cell culture

Bioreactor operations

DoE

Data analysis

Cross-functional collaboration

Education

B.S. in Chemical Engineering, Biochemical Engineering, Biotechnology, Biology, Biochemistry, or related discipline; MS with 3+ years; or Ph.D.

Tools

Cell counting

Metabolite analysis

Protein quantification

Chromatography

Electrophoresis

Job description

Thermo Fisher Scientific in Massachusetts is seeking a hands‑on Bioprocess Development Scientist/Engineer III to advance cell culture and analytical workflows within the Bioprocess Design Center. You will design experiments, troubleshoot bioreactors, analyze data, and translate results into scalable processes.

The role involves collaboration across upstream, downstream, analytics, automation, R&D, and customer programs, with a focus on scalable, validated workflows and cross‑functional