Bioinformatics Scientist

Arc Bio; Scotts Valley (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Fortune 500-level benefits

Job summary

Dovetail Genomics, based in Santa Cruz, CA, is seeking a Bioinformatics Scientist to advance clinical applications of proximity ligation technology. The role emphasizes developing advanced NGS analytics, working with cancer genomics, and collaborating across computational biology, molecular biology, commercial, and finance teams in Scotts Valley.

The ideal candidate will have a PhD and a track record in building analytical methods, with strong Python skills and experience handling large

Qualifications

• PhD in bioinformatics, computational biology, or equivalent; postdoc/industry experience a plus.
• Experience developing and implementing novel bioinformatics algorithms and pipelines.
• Extensive experience processing, integrating, and visualizing large multi-omics datasets (WGS, RNA-Seq, etc.).
• Proficiency with agentic AI for robust code development and scientific workflows.
• Experience with human pangenome and pangenome-based analysis is a plus.
• Expertise in Python programming and ability to learn new bioinformatics resources.
• Experience in Linux-based cloud computing environments (AWS preferred).
• Ability to quickly become an expert in new fields.
• Exceptional depth in cancer genomics, oncology, or related fields.
• Excellent written, presentation, and verbal communication skills.

Responsibilities

• Investigate and drive development of novel analytical methods for large Hi-C datasets.
• Collaborate with multi-disciplinary R&D teams on assay development & benchmarking.
• Support production and commercial teams with data analysis and interpretation.
• Regularly present work to diverse audiences, internally and externally.
• Contribute bioinformatics-focused white papers, posters, and publications.

Skills

Python programming

Cancer genomics

Multi-omics integration

Bioinformatics algorithms

Agentic AI for workflows

Data visualization

Independent / self-starter

Education

PhD in bioinformatics, computational biology, or equivalent

Tools

Linux

AWS cloud

Git

Snakemake / workflow tools

Job description

Dovetail Genomicsis an EdenRoc Sciences startup company based in Santa Cruz, CA developing cutting-edge genomics technologies for vastly improving genome assembly, uncovering critical structural variation information, as well as many applications for studying epigenetics. We are a diverse, talented, multi-disciplinary team innovating in the field of genomics, with the goal of leaving a lasting impact on the world by providing researchers and clinicians with tools for better informing biological understanding.

This role is located in Scotts Valley offices as we find one-on-one in person collaboration very valuable.

We are looking for an outstandingBioinformatics Scientisttodrivenevelopment of newclinicalapplications ofthe proximity ligation technology created by Dovetail Genomics. The ideal candidate will have a proven track record of developing advanced NGS-based analytical methods,ideallywith a focus on cancer genomics. Prior experience with proximity ligation (Hi-C) is not required, but it is expected that it will be bepicked upquickly.He/she should be driven bydeveloping impactfulproducts andenjoy working ina multi-disciplinary environment. This position will interact closely with colleagues in computational biology,molecular biology,commercial, and finance.

The roleofBioinformatics Scientist requires a high level of scientific accomplishment, innovative thinking, and entrepreneurial spirit.Individuals applying for this position must becreative,self-starters, strategic thinkers, action-oriented, flexible in changing direction and methods, thrive in a fast-paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contributionwith a minimum of hands‑on supervision.

Key Responsibilities

• Investigate and drive the development of novel analytical methods that leverage large Hi-C datasets to enable new products and services.

• Collaborateclosely withmulti-disciplinaryR&Dteams on assay development & benchmarking.

• Support production & commercial development teams with data analysis and interpretation.

• Regularly present your work both internally and externally, effectively communicating your methods and results to audiences with diverse scientific and non-scientific backgrounds.

• Contribute and author bioinformatics-focused white papers, posters, and publications.

SkillsAndBackground

• PhD inbioinformatics, computational biology, or equivalent. Postdoctoral and/or industry experienceis a major plus.

• Experience developing and implementing novel bioinformatics algorithms and pipelines.

• Extensive experience processing, integrating, and visualizing large, multi-omics datasets (WGS, RNA-Seq, etc.).

• Proficiency with agentic AI for robust code development and scientific workflows.
• Experience with the human pangenome and pangenome-based analysis is a plus.
• Expertise in Python programming and demonstrated ability to learn and adopt bioinformatics techniques and resources.
• Experience developing within a Linux-based cloud-computing environment (AWS preferred).
• Ability to quickly become an expert in new fields.

• Exceptional technical depth incancergenomics, cancer biology, oncology,or similar.
• Excellent written, presentation, and verbal communication skills.

As a full-time Dovetail Genomics employee, you will receive Fortune 500 level benefits including comprehensive medical, dental, and vision coverage, life and disability insurance, matching 401k plan, and generous paid time off. You will work in a beautiful facility nestled in the Santa Cruz Mountains with walking paths and on-site health club.

Dovetail Genomics is an equal opportunity employer.