Bioinformatics Engineer (Hybrid)

Quest Diagnostics Incorporated; Baltimore (MD); On-site; USD 95,000 - 125,000; Full time

Benefits offered by this job

Day 1 Medical

Blueprint for Wellness

Vacation and Health/Flex Time

401(k) matching

Employee stock purchase plan

Life and disability insurance

Job summary

Quest Diagnostics Incorporated is seeking a Bioinformatics Scientist to design and maintain cloud-based infrastructures for genomic data analysis from our MRD assays. You will work with cross‑functional teams to integrate pipelines with LIMS and ensure secure, compliant operations in clinical diagnostics.

The role emphasizes Python/Nextflow development, cloud-native design (AWS), and collaboration with clinical laboratories in the US and Europe, with a potential annual bonus eligibility.

Qualifications

• Background in software or infrastructure engineering with bioinformatics experience.
• Proficiency with bioinformatics pipeline workflow management (Nextflow preferred).
• Hands-on experience with cloud-native infrastructure (AWS) for storage, batch computing and serverless apps.

Responsibilities

• Develop & maintain cloud infrastructure for scalable genomic data analysis.
• Implement and optimize Python and Nextflow bioinformatics workflows.
• Integrate bioinformatics pipelines with LIMS to streamline data processing.
• Ensure IT security and privacy controls aligned with corporate policies.
• Apply software engineering best practices for scalable pipelines.
• Develop and manage databases and apps for QC and assay monitoring.
• Document and validate bioinformatics systems per regulatory quality standards.

Skills

Python

Nextflow

AWS

TypeScript

REST APIs

Git

CI/CD

Education

Bachelor's Degree

Master's Degree

Tools

Nextflow

Cromwell

CWL

Terraform

AWS CDK

Job description

Pay Range: $95,000.00 - $125,000.00 / year

Salary offers are based on a wide range of factors including relevant skills, training, experience, education, and, where applicable, certifications obtained. Market and organizational factors are also considered. Successful candidates may be eligible to receive annual performance bonus compensation.

Benefits Information

• Day 1 Medical, supplemental health, dental & vision for FT employees who work 30+ hours
• Best-in‑class well‑being programs
• Annual, no‑cost health assessment program Blueprint for Wellness
• healthyMINDS mental health program
• Vacation and Health/Flex Time
• 6 Holidays plus 1 "MyDay" off
• FinFit financial coaching and services
• 401(k) pre‑tax and/or Roth IRA with company match up to 5% after 12 months of service
• Employee stock purchase plan
• Life and disability insurance, plus buy‑up option
• Flexible Spending Accounts
• Annual incentive plans
• Matching gifts program
• Education assistance through MyQuest for Education
• Career advancement opportunities
• and so much more!

About Haystack Oncology

Haystack Oncology, now part of Quest Diagnostics, is a next‑generation liquid biopsy company focused on advancing tumor‑informed minimal residual disease (MRD) testing. Our proprietary technology enables highly sensitive and specific detection of circulating tumor DNA (ctDNA), improving patient outcomes through earlier detection of residual disease.

As we continue to expand our assay portfolio and bring cutting‑edge diagnostics to the public, we are seeking a skilled Bioinformatics Scientist to join our growing team. This role will play a critical part in supporting clinical production testing, clinical trials, and assay R&D for Quest Diagnostics laboratories in the US and Europe.

Role Overview

As a Bioinformatics Scientist, you will develop and maintain cloud‑based computational infrastructure for the analysis of genomic data from our proprietary MRD assays. You will work cross‑functionally with laboratory, LIMS, and IT teams to ensure seamless integration of bioinformatics workflows with clinical and research operations.

Responsibilities

• Develop & maintain cloud infrastructure for scalable and efficient genomic data analysis.
• Implement and optimize Python and Nextflow bioinformatics workflows.
• Integrate bioinformatics pipelines with Laboratory Information Management Systems (LIMS) to streamline data processing.
• Ensure compliance with IT security and privacy controls, aligning with Quest Diagnostics' corporate policies.
• Apply software engineering best practices, contributing to the scalability, robustness, and maintainability of bioinformatics pipelines.
• Develop and manage databases and applications for quality control (QC) and assay performance monitoring.
• Document and validate bioinformatics systems in compliance with regulatory and quality standards for clinical diagnostics.

Qualifications

Required

• Background in software or infrastructure engineering, with experience in bioinformatics.
• Proficiency in bioinformatics pipeline workflow management, particularly Nextflow (preferred), Cromwell, or CWL.
• Hands‑on experience developing cloud‑native infrastructure (AWS preferred) for storage, batch computing, and serverless applications.
• Expertise in infrastructure as code (IaC) technologies such as Terraform or AWS CDK.
• Strong programming skills in Python, JavaScript/TypeScript, R, or other relevant scripting languages.
• Experience with API development and integration, particularly JSON‑based RESTful APIs.
• Deep understanding of version control (Git), CI/CD best practices, and software development lifecycle (SDLC).
• Ability to work cross‑functionally in a multi‑disciplinary environment with minimal supervision.
• Strong problem‑solving, analytical, and troubleshooting skills, with the ability to diagnose and resolve technical issues.
• Excellent verbal and written communication skills in English, with the ability to translate technical concepts for non‑technical stakeholders.

Preferred

• Experience in a clinical diagnostics or regulated environment (e.g., CLIA, CAP, IVDR, FDA) with knowledge of software validation and regulatory requirements.
• Understanding of controlled processes, environment management, and quality control systems in a clinical setting.
• Familiarity with DevOps methodologies.

Education

• Bachelor's Degree (Required)
• Master's Degree (Preferred)

Quest Diagnostics honors our service members and encourages veterans to apply.

While we appreciate and value our staffing partners, we do not accept unsolicited resumes from agencies. Quest will not be responsible for paying agency fees for any individual to whom an agency has sent an unsolicited resume.

Equal Opportunity Employer: Race/Color/Sex/Sexual Orientation/Gender Identity/Religion/National Origin/Disability/Vets or any other legally protected status.