Bioinformatics Analyst I - Sun Lab

001 University of Rochester; United States; On-site; USD 64,000 - 96,000; Full time

Job summary

University of Rochester seeks a computational bioinformatics professional to support the Sun lab on cancer evolution, tumor immunology, and multi-omics data integration. The role develops pipelines for RNA-seq, spatial transcriptomics, and epigenetic profiling.

The candidate will collaborate with experimental staff, perform QC and statistical modeling, and help prepare manuscripts and grants. Master’s degree preferred; 1 year of relevant experience is required.

Qualifications

• Bachelor’s degree required.
• Master’s degree preferred.
• 1 year of relevant experience required or equivalent combination of education and experience.
• Experience with genomics and bioinformatics in a clinical laboratory including setting up, testing and maintaining bioinformatics workflows required.

Responsibilities

• Contributes to computational analysis of data from multiple research projects in the Sun lab, focusing on cancer evolution, tumor immunology, and multi-omics data integration.
• Develops, maintains, and applies bioinformatic pipelines for bulk and single-cell RNA sequencing, spatial transcriptomics, epigenetic profiling, and proteomics.
• Collaborates with experimental researchers to design studies, interpret results, and support manuscript and grant preparation.
• Contributes to reproducible computational workflows and data-management infrastructure in the lab.

Skills

Python

R

Bash scripting

STAR

TopHat

DeSeq

GATK

minimap2

Education

Bachelor's degree

Master degree

Tools

SRA

STAR

TopHat

DeSeq

BWA

GATK

minimap2

Job description

As a community, the University of Rochester is defined by a deep commitment to Meliora - Ever Better. Embedded in that ideal are the values we share: equity, leadership, integrity, openness, respect, and accountability. Together, we will set the highest standards for how we treat each other to ensure our community is welcoming to all and is a place where all can thrive.

Job Location (Full Address): 601 Elmwood Ave, Rochester, New York, United States of America, 14642 Opening: Worker Subtype: Regular Time Type: Full time Scheduled Weekly Hours: 40 Department: 400020 Microbiology & Immunology M&D Work Shift: UR - Day (United States of America) Range: UR URG 111

Compensation Range: $63,815.00 - $95,723.00 The referenced pay range represents the minimum and maximum compensation for this job. Individual annual salaries/hourly rates will be set within the job's compensation range, and will be determined by considering factors including, but not limited to, market data, education, experience, qualifications, expertise of the individual, and internal equity considerations.

Responsibilities

Contributes to computational analysis of data generated across multiple research projects in the Sun lab, with a focus on cancer evolution, tumor immunology, transposable element biology, and multi-omics data integration. Develops, maintains, and applies bioinformatic pipelines for bulk and single cells RNA sequencing, spatial transcriptomics , epigenetic profiling, epigenomic profiling, proteomics, and genomic analysis. Perform data processing, quality control, statistical modeling, machine learning, and integrative analysis to identify biologically meaningful patterns and generate testable hypotheses. Collaborate closely with experimental researcher to design studies, interpret results, and support manuscript and grant preparation. Contributes to the development of reproducible computational workflows, data visualization tools, and laboratory data-management infrastructure while helping establish and expand the laboratory’s computational research capabilities.

Essential Functions

Responsible for the preparation, maintenance, curation, and analysis of data from high-throughput sequencing (HTS) projects and other projects that generate and complement genomic data. Contributes to the design and interpretation of experimental projects and results. Prepares data and reports for discussion, use and interpretation by investigators. Performs computational analysis include but not limited to statistical test, machine learning, and mathematical modeling. Prepares reports, presents findings in both oral presentation and paper writing. Provides standard bioinformatics analyses, such as unsupervised clustering, differential expression and data visualization, as well as applying more sophisticated algorithms for inference of cell state, gene regulatory networks, and cell-cell interactions. Completes maintenance of computational pipelines, data management, and sharing, consulting with researchers on analytical methods and carrying out custom bioinformatics projects. Other duties as assigned.

Minimum Education & Experience

• Bachelor’s degree required
• Master degree preferred
• 1 year of relevant experience required or equivalent combination of education and experience required
• Experience with genomics and bioinformatics in a clinical laboratory including setting up, testing and maintaining bioinformatics workflows required

Knowledge, Skills & Abilities

• Demonstrated ability to achieve results in a deadline driven environment with multiple priorities and multiple stakeholders required
• Ability to learn and deliver work to audience with varied backgrounds required
• Experience/proficiency with python/java/C++/R, bash scripting, statistical programming using R or related tools, web-development, pipeline development, and database query SRA downloading and ability to prototype software solutions for data analysis and use of next generation sequencing tools such as STAR(solo), TopHat, DeSeq, BWA, GATK, minimap2 and others required.

The University of Rochester is committed to fostering, cultivating, and preserving an inclusive and welcoming culture to advance the University’s Mission to Learn, Discover, Heal, Create – and Make the World Ever Better.

In support of our values and those of our society, the University is committed to not discriminating on the basis of age, color, disability, ethnicity, gender identity or expression, genetic information, marital status, military/veteran status, national origin, race, religion, creed, sex, sexual orientation, citizenship status, or any other characteristic protected by federal, state, or local law (Protected Characteristics).

This commitment extends to non-discrimination in the administration of our policies, admissions, employment, access, and recruitment of candidates, for all persons consistent with our values and based on applicable law.

Located in western New York, Rochester is our namesake and our home. One of the world’s leading research universities, Rochester has a long tradition of breaking boundaries—always pushing and questioning, learning and unlearning. We transform ideas into enterprises that create value and make the world ever better.

If you’re looking for a career in higher education or health care, the University of Rochester may offer the perfect opportunity for your background and goals. At the University of Rochester, we are committed to fostering, cultivating, and preserving an inclusive and welcoming culture and are united by a strong commitment to be ever better—Meliora. It is an ideal that informs our shared mission to ensure all members of our community feel safe, respected, included, and valued.