Bioinformatician I

2200 The Brigham and Women's Hospital, Inc.; Boston (MA); Hybrid; USD 75,000 - 110,000; Full time

Job summary

The Brigham and Women's Hospital, Inc. is seeking a Bioinformatician to develop and validate predictive models from large multi-omic and clinical data. The role emphasizes reproducible workflows, HPC optimization, and cross-cohort data processing.

You will collaborate with investigators to ensure rigorous model validation across datasets and horizons, contributing to manuscripts and grant analyses as needed.

Qualifications

• Bachelor's in Computational Biology or related field required.
• Master's degree in related field preferred.
• 0-1 year Computational Sciences experience; 3+ years preferred.
• Strong analytical, data modeling, problem solving and troubleshooting skills.

Responsibilities

• Analyze complex biological and multi-omic data using bioinformatics tools.
• Develop, implement and maintain reproducible data analysis pipelines.
• Collaborate with research teams to understand data analysis needs.
• Lead interpretation and presentation of analytical results.
• Troubleshoot computational, analytical, and data-quality issues.
• Document methods and code to ensure reproducibility and auditability.
• Optimize workflows for large-scale HPC environments.

Skills

Bioinformatics tools

Data analysis

Pipeline development

Statistics

HPC

Model validation

Cross-cohort analysis

Education

Bachelor's in Computational Biology or related field

Master's degree preferred

Tools

Open-source bioinformatics software

Job description

Job Summary

This is a one-year, fixed-term position with an anticipated duration of 12 months.

Bioinformatician: Computational Omics and Predictive Modeling

Responsible for developing, implementing, adapting, and validating computational prediction models using large-scale multi-omic, clinical, and phenotypic data. The role develops reproducible analytical workflows, optimizes code for high-performance computing, addresses cross-cohort differences in data processing and feature availability, and evaluates model performance in independent datasets across clinically relevant prediction horizons. Works collaboratively with investigators and external partners to ensure rigorous, reproducible, and interpretable model validation.

Essential Functions (Key Roles & Responsibilities)

• Independently conduct and support analysis of complex biological and multi-omic data using bioinformatics tools and software.
• Perform data processing, quality control, and database maintenance.
• Collaborate with research teams to understand their data analysis needs.
• Develop, implement, validate, and maintain reproducible data analysis pipelines.
• Conduct advanced statistical and bioinformatic analyses and data visualization.
• Lead or substantially contribute to interpretation and presentation of analytical results.
• Working under very general supervision, the Bioinformatics Analyst will have demonstrated independent design and innovation in one or more of the following areas of specialization: algorithm development, data analysis, quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, or report development.
• Develop and validate multi-omic risk prediction models in a series of large cohorts.
• Design and evaluate statistical and machine-learning approaches for high-dimensional biological and clinical data.
• Independently troubleshoot computational, analytical, and data-quality issues.
• Document methods, code, assumptions, and analytic decisions to ensure reproducibility and auditability.
• Optimize workflows for large-scale and high-performance computing environments.
• Conduct data analysis to uncover trends, patterns, and anomalies.
• Collaborate effectively with cross-functional teams.
• Support research security and compliance oversight by collaborating with the Institutional Review Board and other research governing bodies.
• Adhere to rigorous principles of reproducible research and data documentation.
• Substantially contribute to manuscripts, abstracts, reports, presentations, and grant-related analyses (e.g., scientific literature, reports, journal publications and presentations).
• Performs other duties as assigned.
• Complies with all policies and standards.

Qualifications

Education: Bachelor's Degree in Computational Biology or Related Field of Study required. Master's Degree in Related Field of Study preferred.

Experience: Computational Sciences Experience: 0-1 year. Computational Sciences Experience: 3+ years preferred.

Knowledge, Skills and Abilities: Demonstrated experience in infrastructure, programming languages, and computational sciences. Demonstrated ability working with open-source bioinformatics software. Possess strong analytical skills, including critical thinking, data modeling, problem solving, and troubleshooting. Strong organizational and interpersonal skills. Ability to effectively communicate, both orally and in writing, to all levels of staff. Excellent time management skills.

Additional Job Details (if applicable)

• Remote Type: Hybrid
• Work Location: 1620 Tremont Street
• Scheduled Weekly Hours: 40
• Employee Type: Regular Work Shift Day (United States of America)
• Pay Range: $75,275.20 - $109,553.60/Annual
• Grade: 6

In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

EEO Statement

The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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