Automation Service Engineer I/II, Oncology

BillionToOne; Menlo Park (CA); On-site; USD 102,000 - 145,000; Full time

Benefits offered by this job

Health benefits

On-site lunches

EV charging

401k match

Parental leave

Job summary

BillionToOne in Menlo Park, CA is hiring an Automation Service Engineer I/II, Oncology to support lab operations, troubleshoot and maintain sequencing equipment in a regulated environment.

The role requires strong root-cause analysis, excellent documentation (GDP) and clear communication; onsite work with cross-functional teams and vendors.

BS degree, 3+ years in lab equipment operation, preferably high-throughput molecular biology tools; this is a hands-on, impact-focused position.

Qualifications

• BS degree in a scientific discipline.
• 3+ years operating and troubleshooting lab equipment, preferably high-throughput molecular biology equipment such as liquid handlers.
• Strong customer‑focused service experience.
• Ability to engage in constructive dialogue and maintain transparency.
• Attention to detail and accuracy.
• Experience in CLIA or similar regulated environment preferred.

Responsibilities

• Provide service, support, and troubleshooting for automated processes and instrumentation.
• Perform and coordinate maintenance work on laboratory equipment.
• Troubleshoot, conduct root cause analysis, and problem solving on lab instruments.
• Carry out Installation, Operational, and Process Qualifications on new equipment as necessary.
• Collaborate with Quality Control to ensure documentation is completed accurately per regulatory requirements.
• Coordinate with vendors as required for equipment issues.
• Maintain equipment parts inventory and organized records.
• Prepare documentation for equipment operation and maintenance.
• Propose and design plans for process improvements.
• Represent equipment and automation teams in cross-functional meetings.
• Undertake special projects as assigned.

Skills

Root cause analysis

Customer service

Communication

Problem solving

Multi-tasking

Education

Bachelor's degree in a scientific discipline

Tools

Liquid handling robots

NGS instruments

Automation software

Job description

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We are seeking an Automation Service Engineer I/II, Oncology to provide service support to the laboratory operations team and to be responsible for troubleshooting, maintenance, and repair of laboratory equipment utilized. This position requires a candidate that is strong in root cause analysis, application support and repair of equipment commonly used in the Next Generation Sequencing workflow. The role requires a detail-oriented candidate with experience in a regulated environment, exceptional documentation (GDP) abilities and strong written and verbal communication skills. This is an onsite position in our facility in Menlo Park, CA.

Shift Schedule

Monday - Friday, or Tuesday - Saturday PM shift

Responsibilities

• Provide service, support, and troubleshooting for automated processes and instrumentation.
• Perform and coordinate maintenance work on laboratory equipment.
• Troubleshoot, conduct root cause analysis, and problem solving on lab instruments.
• Carry out Installation, Operational, and Process Qualifications on new equipment as necessary.
• Collaborate with Quality Control to ensure all documentation is completed accurately and in accordance with regulatory requirements.
• Effectively coordinate with vendors as required for equipment issues.
• Maintain equipment parts inventory and well-organized equipment records.
• Prepare documentation as needed for equipment operation and maintenance.
• Propose and design plans for process improvements.
• Represent the equipment and automation teams in cross-functional meetings.
• Undertake special projects as assigned.

Requirements

• BS degree in a scientific discipline.
• 3+ years of experience in operating and troubleshooting laboratory equipment, preferably high-throughput molecular biology equipment, especially liquid handlers
• Strong customer focused service experience.
• Ability to engage in constructive dialogue, challenge concerns and maintain transparency.
• Proficiency in problem-solving with limited direction and making confident decisions.
• Attention to detail and accuracy.
• Solid understanding of statistical analyses relevant to automated lab processes.
• Strong multi-tasking ability with a focus on prioritization.
• Experience in troubleshooting complex scripts is an added advantage.
• Experience working in a CLIA or similar regulated environment is preferred.
• Ability to work effectively in a team and build strong relationships.
• Self-motivated with a high level of initiative.
• Drive for continual improvement.

Nice-to-Haves

• Familiarity with Molecular Biology techniques, including next generation sequencing.
• Experience with data science / data engineering in an automated laboratory environment.
• Experience developing training programs and performing knowledge transfer.

Benefits And Perks

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package range of up to $179,169 per year, including a base pay rate of $48.95 - $69.57 per hour.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

For more information about how we protect your information, we encourage you to review our Privacy Policy.

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.

Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.

Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com