Associate Staff Scientist, Intestinal Organoid Development

Cincinnati Children's Hospital Medical Center; Cincinnati (OH); On-site; USD 80,000 - 120,000; Full time

Job summary

Cincinnati Children's Hospital Medical Center is seeking an Associate Staff Scientist to advance and scale human stem cell-derived intestinal organoid technologies for disease modeling, therapeutic discovery, and regenerative medicine. The role spans development, validation, and translational applications within a collaborative team.

You will contribute to scalable organoid platforms, automate workflows, and publish findings while mentoring junior staff and coordinating with clinical and

Qualifications

• PhD in Biology, Bioengineering, Developmental Biology, Stem Cell Biology, Biomedical Engineering, or a related field.
• Strong background in developmental biology, stem cell biology, tissue engineering, regenerative medicine, intestinal biology, or advanced in vitro model systems.
• Experience with human induced pluripotent stem cells (iPSCs), adult stem cells, intestinal biology, developmental biology, or organoid model systems.
• Extensive experience with mammalian cell culture techniques and downstream molecular and cellular assays.
• Hands-on experience in molecular, cellular, and imaging-based characterization techniques, including flow cytometry, immunostaining, histology, confocal microscopy, high-content imaging, qPCR, transcriptomics, and single-cell analysis.
• Experience designing and executing independent research projects.
• Excellent written, verbal, and interpersonal communication skills.
• Demonstrated ability to work effectively in a collaborative and multidisciplinary team environment.
• Strong analytical, organizational, and problem-solving skills.
• Ability to manage multiple projects simultaneously in a fast-paced research environment.

Responsibilities

• Lead the development, optimization, and characterization of iPSC-derived intestinal organoid models for disease modeling, therapeutic discovery, regenerative medicine, and translational applications.
• Establish and implement novel protocols for stem cell differentiation, organoid culture, maturation, and functional assessment.
• Investigate mechanisms of intestinal development, epithelial regeneration, and tissue maturation using human stem cell-derived organoid systems.
• Contribute to the development and preclinical evaluation of stem cell-derived intestinal tissues and regenerative medicine strategies aimed at restoring intestinal function.
• Characterize organoid models using molecular, cellular, biochemical, imaging, and functional approaches.
• Design, execute, analyze, and interpret experimental studies independently.
• Collaborate closely with experts in developmental biology, bioengineering, automation, imaging, data science, surgery, and translational medicine to advance organoid platforms and workflows.
• Contribute to the development of scalable and automated organoid manufacturing and screening technologies.
• Present scientific findings at laboratory meetings, seminars, and national or international conferences.
• Prepare manuscripts, abstracts, technical reports, grant applications, and other scientific communications.
• Mentor and supervise junior scientists, trainees, and laboratory personnel.
• Build strong collaborative relationships with academic, clinical, industry, and regulatory partners.

Skills

iPSC culture

Organoid models

Mammalian cell culture

Flow cytometry

Immunostaining

Confocal microscopy

qPCR

Transcriptomics

Single-cell analysis

Collaborative teamwork

Education

PhD in Biology/related field

Tools

Automation platforms

Liquid handling systems

Robotic workflows

High-throughput screening

Job description

Cincinnati Children's Hospital Medical Center is seeking an Associate Staff Scientist to advance and scale human stem cell-derived intestinal organoid technologies for disease modeling, therapeutic discovery, and regenerative medicine. The role spans development, validation, and translational applications within a collaborative team.

You will contribute to scalable organoid platforms, automate workflows, and publish findings while mentoring junior staff and coordinating with clinical and