Associate Scientist, Potency & Cell-Based Assay Development

Regeneron Pharmaceuticals; Village of Tarrytown (NY); On-site; USD 70,000 - 110,000; Full time

Job summary

Regeneron Pharmaceuticals in Tarrytown, NY is seeking an Associate Scientist to develop, optimize, and qualify cell-based potency assays supporting gene therapy programs. You will perform qPCR, ELISA, and Western blot-based assays with meticulous data handling and reproducibility.

You will maintain mammalian cell cultures and operate instruments like flow cytometers and plate readers, contributing to data generation and cross-functional discussions.

Qualifications

• A Bachelor with at least 3 years of relevant laboratory experience, or a Masters with 0-2 years of experience
• Hands-on experience with cell-based assays, preferably including potency assays.
• Experience with qPCR, ELISA, and CE-Western blotting.
• Strong mammalian cell culture skills and the ability to execute experiments independently and reliably.
• Exceptional organizational skills and the ability to multitask across multiple workflows in a fast-paced environment
• Preferred experience includes mRNA expression measurement using qPCR, Luciferase reporter-based assays, immunofluorescence staining and imaging-based assay readouts, automated imaging or plate-based analytical platforms, and GraphPad Prism data analysis experience

Responsibilities

• Develop, optimize, and qualify cell-based potency assays to support gene therapy programs.
• Execute qPCR, ELISA, Western blot, and related molecular or cell-based assays with strong attention to detail and reproducibility.
• Maintain healthy adherent and non-adherent mammalian cell cultures, including engineered or stable cell lines used in assay development.
• Operate laboratory instruments such as flow cytometers, plate readers (SpectraMax, EnVision), and other automated systems to support assay execution and data generation.
• Analyze data using appropriate statistical methods and document experiments, results, and conclusions clearly in the electronic lab notebook (ELN).
• Present findings in group and cross-functional meetings and contribute to assay troubleshooting, optimization, and technical decision-making.
• Support sample testing for preclinical manufacturing process and product characterization.
• Help transfer qualified assays to GMP laboratories.

Skills

Cell-based assays

qPCR

ELISA

Western blot

Mammalian cell culture

Data analysis

Independent experimentation

Education

Bachelor's degree in life sciences

Master's degree in related field

Tools

Flow cytometer

Plate readers (SpectraMax, EnVision)

ELN (Electronic Lab Notebook)

Automated systems

Job description

Regeneron Pharmaceuticals in Tarrytown, NY is seeking an Associate Scientist to develop, optimize, and qualify cell-based potency assays supporting gene therapy programs. You will perform qPCR, ELISA, and Western blot-based assays with meticulous data handling and reproducibility.

You will maintain mammalian cell cultures and operate instruments like flow cytometers and plate readers, contributing to data generation and cross-functional discussions.