Associate Scientist, Immunology

askbio; Philadelphia (Philadelphia County); On-site; USD 90,000 - 130,000; Full time

Job summary

AskBio Inc. in Philadelphia seeks an Associate Scientist, Clinical Immunology, to advance immunology analyses for our gene therapy programs. You will lead assay development, validation, and real-time immune assessments on clinical study samples, coordinating with the Immunology lab and Clinical team.

The role reports to the Senior Director of Immunology, is full-time and on-site at our Philadelphia site, with opportunities to contribute to cutting-edge translational research.

Qualifications

• Bachelor’s or Master’s in biology, chemistry or related field with relevant experience.
• Strong immunology, cell biology and lab skills required.
• Familiarity with GCP/GLP/GxP labs and LIMS preferred.
• Excellent documentation and communication abilities.

Responsibilities

• Perform complex immunology assays and data analysis with minimal supervision.
• Lead assay development, qualification, validation, and troubleshooting of new methods.
• Coordinate sample receiving and testing with Clinical team and Immunology lab manager.
• Prepare validation reports and study summaries for regulatory compliance.
• Maintain GLP/GxP compliant lab environment and write SOPs for new protocols.
• Mentor junior staff and ensure high-quality data and documentation.

Skills

Immunology

Cell biology

Cell culture

GxP familiarity

LIMS familiarity

Documentation skills

MS Office

Education

Bachelor’s degree in biology/chemistry

Master’s degree in biology/chemistry

Tools

LabVantage LIMS

PCR instruments

Job description

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.

Our vision:

Pioneering science to create transformative molecular medicines.

Our mission:

Lead innovative science and drive clinical outcomes to transform people's lives.

Our principles:

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission.We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Position Summary

The Associate Scientist, Clinical Immunology, is one of the key laboratory members who will have an opportunity to contribute to the understanding of AAV Immunogenicity by performing analyses on clinical study samples using immunological assays in support of our gene therapy programs. The Associate Scientist will lead activities in the lab to drive assay development and validation, perform real-time immune assessments of clinical studies, as well as support clinical sample coordination and management. This is an excellent opportunity for a candidate who is looking to build upon his/her experience in Cell Biology and Immunology lab skills as they transition to a more scientific role in solving challenges associated with gene therapy to advance programs through clinical trial stages.

Reporting to the Senior Director of Immunology, this position is full-time, on-site, located at our Philadelphia site.

Job Responsibilities

• Perform complex assays without supervision
• Perform assay development of new clinical assays which may include the optimization, qualification, validation, and troubleshooting of new analytical methods
• Perform data analysis and interpret the results accurately
• Prepare validation reports and summaries
• Coordinate with Clinical team and/or Immunology lab manager for sample receiving and testing
• Support sample receiving and processing workflow
• Participate in team and clinical program meetings as needed to report results, discuss data and address program needs
• Build and maintain a compliant GxP lab environment and adhere to GLP/GcLP guidelines
• Author standard operating procedures (SOPs) for new assay protocols and use of new laboratory equipment
• Maintain a laboratory notebook or binder with worksheets recording details of performed experiments according to good documentation practices
• Train and mentor Research Associates and junior members of the laboratory

Minimum Requirements

• Bachelor’s degree in biology, chemistry, or related field and 8+ years’ relevant work experience; or Masters degree in biology, chemistry, or related field and 4+ years of relevant work experience
• Intermediate lab skills in cell biology, cell culture, immunology, reagent preparation, and adherence to biosafety and chemical use guidelines
• Familiarity with GCP/GLP/GxP lab standards and practices
• Familiarity with LIMS
• Basic office skills using a PC and working with MS office tools (Word, Excel and PowerPoint)
• Must be self-motivated, organized, capable of working independently as well as a team contributor
• Strong oral and written communication skills, particularly in writing technical documents such as SOPs, assay validation plans, reports and clinical sample testing plans and reports. Excellent interpersonal skills with the ability to interact effectively with teams, internally and externally
• Ability to work independently with minimal supervision under remote management as well as to work collaboratively with a broader team and across functional departments

Preferred Education, Experience and Skills

• Experience in immunoassays such as ELISA, ELISPOT/FluoroSpot, neutralizing antibody, MSD, cytokine release and flow cytometry
• Previous experience working with human clinical samples, blood processing and downstream testing
• Experience with LabVantage LIMS
• Familiarity with statistical analysis
• Flexible schedule to accommodate real-time and urgent sample analysis

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job-related requirements.