Associate Research Scientist

System One; Alameda (CA); On-site; USD 47,000 - 63,000; Full time

Job summary

System One is seeking an Associate Research Scientist in Alameda, CA for a contract role focusing on small molecule drug discovery. You will develop and optimize HTS biochemical and biophysical assays, and drive MoA studies while collaborating with internal teams.

The position requires hands-on SPR proficiency, HTS assay development for 1536/384-well formats, and familiarity with lab automation. Strong communication and meticulous record-keeping are essential.

Qualifications

• Hands-on experience with biophysical and biochemical assay technologies relevant to small molecule drug discovery is required.
• Thorough knowledge of surface plasmon resonance (SPR) techniques for characterizing small molecule-protein complexes is highly desired.
• Experience with assay development for HTS applications and designing workflows is required.
• Significant experience developing assays in 1536- and 384-well plate formats is required.
• Hands-on experience with laboratory automation equipment such as liquid handlers, dispensers, and readers is a strong plus.
• Broad understanding of biophysical (SPR, MST, NanoDSF, BLI, thermal shift assays, etc.) and biochemical assays (HTRF, AlphaLISA, Lumit, MSD, ELISA, FP, GLO, etc.)
• Ability to apply automation tools to assay development and execution
• Awareness of current scientific literature and advancements in drug discovery technologies
• Experience with heterobifunctional degraders or molecular glues is a plus
• Education: Bachelor’s degree in related discipline + 5 years of related experience; or Associate’s degree + 7 years; High School Diploma/GED + 9 years
• Excellent laboratory, communication, and interpersonal skills

Responsibilities

• Independently develop, optimize and execute small molecule compound profiling and HTS biochemical and biophysical assays
• Consistently contribute to the design, planning, and execution of HTS campaigns and mechanism of action (MoA) studies
• Independently nominate, evaluate, and implement new technologies, protocols, and workflows to support projects from hit finding, hit validation, to lead optimization stages, as well as MoA studies
• Collaborate with internal teams and departments to discuss and resolve project and/or department needs
• Present data and reports on project status to department head/manager and at research meetings
• Communicate scientific results to manager, department, and project team partners and/or collaborators
• Maintain laboratory notebooks in a complete, consistent, and concise manner in accordance with company policies
• Comply with company health and safety policies and general laboratory practices
• Other responsibilities, as assigned

Skills

Biochemical assay development

HTS workflow design

SPR techniques

Automation in assay development

Data presentation

Education

Bachelor’s degree + 5 years experience

Associate’s degree + 7 years

High School Diploma/GED + 9 years

Tools

SPR instrumentation

Liquid handling robots

HTS platforms

Job description

Job Title: Associate Research Scientist
Location: Alameda, CA
Type: Contract
Compensation: 40/hr
Work Model: Onsite – onsite
Hours: 40.0

Responsibilities

• Independently develop, optimize and execute small molecule compound profiling and HTS biochemical and biophysical assays
• Consistently contribute to the design, planning, and execution of HTS campaigns and mechanism of action (MoA) studies
• Independently nominate, evaluate, and implement new technologies, protocols, and workflows to support projects from hit finding, hit validation, to lead optimization stages, as well as MoA studies
• Collaborate with internal teams and departments to discuss and resolve project and/or department needs
• Present data and reports on project status to department head/manager and at research meetings
• Communicate scientific results to manager, department, and project team partners and/or collaborators
• Maintain laboratory notebooks in a complete, consistent, and concise manner in accordance with company policies
• Comply with company health and safety policies and general laboratory practices
• Other responsibilities, as assigned

Requirements

• Hands-on experience with biophysical and biochemical assay technologies relevant to small molecule drug discovery is required
• Thorough knowledge of surface plasmon resonance (SPR) techniques for characterizing small molecule-protein complexes is highly desired
• Experience with assay development for HTS applications and designing workflows is required
• Significant experience developing assays in 1536- and 384-well plate formats is requiredli>
• Hands-on experience with laboratory automation equipment such as liquid handlers, dispensers, and readers is a strong plus
• Broad understanding of biophysical (SPR, MST, NanoDSF, BLI, thermal shift assays, etc.) and biochemical assays (HTRF, AlphaLISA, Lumit, MSD, ELISA, FP, GLO, etc.)
• Ability to apply automation tools to assay development and execution
• Awareness of current scientific literature and advancements in drug discovery technologies
• Experience with heterobifunctional degraders or molecular glues is a plus
• Education: Bachelor’s degree in related discipline + 5 years of related experience; or Associate’s degree + 7 years; High School Diploma/GED + 9 years
• Excellent laboratory, communication, and interpersonal skills

System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.