Associate Manufacturing Scientist I (2nd shift)

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 60,000 - 80,000; Full time

Benefits offered by this job

Excellent benefits package

Job summary

Arrowhead Pharmaceuticals, Inc. is seeking an Associate Manufacturing Scientist I (second shift) in Madison, WI to support large-scale oligonucleotide synthesis and purification while adhering to GLP/GMP protocols.

You will operate synthesis and purification equipment, document operations, and collaborate with cross-functional teams to ensure quality, safety, and on-time production in a fast-paced environment.

Qualifications

• Bachelor's degree or equivalent in a scientific discipline.
• 0-2 years in biotech/pharma manufacturing or lab setting.
• Ability to follow detailed procedures and maintain accurate documentation.
• Strong attention to detail and quality.
• Ability to work independently and in a team, with good communication.

Responsibilities

• Follow batch records, SOPs, and work instructions to detail manufacturing steps.
• Document all operations in batch records and logbooks.
• Comply with GMP protocols.
• Operate large-scale oligonucleotide manufacturing equipment (synthesizer, purification skid, TFF, lyophilizer, reactors, meters, pumps).
• Assist with synthesis and purification of oligonucleotides; prepare reagents and mobile phases; column packing; fraction collection.
• Perform LCMS analysis of oligonucleotides and intermediates.
• Collaborate with Process Development, Analytical Development, Quality Control and QA.

Skills

GMP compliance

Batch records

Documentation

LCMS

Oligonucleotide synthesis

SOP adherence

Education

Bachelor's degree in Chemistry / Biochemistry / Biology / Chemical Engineering or related

Tools

D365 ERP

LCMS instrumentation

Chromatography

Purification systems

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Associate Manufacturing Scientist I (second shift) rolewill involve assisting in the synthesis and subsequent purification steps oflarge scale oligonucleotides. The operator must comply with GLP/GMP protocols andbe able to follow all association SOPs and work instructions when performing anddocumenting operations.

2 nd shift work hours are 1pm - 11:30 pm Monday - Thursday and includes a 10% shift differential.

Responsibilities

• Follow batch records, SOPs, and work instructions to detail
• Document all operations in batch records and logbooks
• Comply with GMP protocols
• Operate large scale oligonucleotide manufacturing equipment (i.e. oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps, etc.)
• Assist other chemists within the Manufacturing group during synthesis and purification of oligonucleotides including
  • Reagent solution preparation
  • Mobile phase preparation
  • Column Packing
  • Fraction collection
• Perform oligonucleotide/intermediate analysis via LCMS
• Communicate with cross-functional groups such as Process Development, Analytical Development, Quality Control, Quality Assurance, etc.
• Maintain a clean work space
• Maintain safety by wearing required personal protective equipment
• Track and update raw material usage in D365 ERP software
• Act as production campaign lead
• Assist with new personnel training

Requirements

• Bachelor's degree in Chemistry, Biochemistry, Biology, Chemical Engineering, or another scientific discipline or equivalent relevant manufacturing experience.
• 0-2 years of laboratory or manufacturing experience in biotechnology, pharmaceutical, chemical, or related industries.
• Ability to follow detailed written procedures and maintain accurate documentation.
• Strong attention to detail and commitment to quality.
• Ability to work independently while collaborating effectively within a team.
• Strong verbal and written communication skills.
• Demonstrated ability to prioritize work in a fast-paced manufacturing environment.

Preferred

• Experience working in a GMP-regulated manufacturing or laboratory environment.
• Hands-on experience with chromatography, filtration, purification, or analytical instrumentation such as LC-MS.
• Familiarity with manufacturing documentation, batch records, or ERP systems.

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.