Associate Director, Translational Toxicology, Preclinical Development

Scorpion Therapeutics; Lexington (MA); On-site; USD 190,000 - 230,000; Full time

Job summary

Scorpion Therapeutics in Lexington, MA seeks a senior leader to lead safety assessment of novel oligonucleotide therapeutics for rare diseases within the Preclinical and Clinical Development Sciences team. You will design and critically evaluate exploratory and GLP toxicology studies and develop preclinical strategies.

You will collaborate across functions including CMC, Regulatory, and Discovery Sciences, provide risk assessments for program teams, and lead investigations into mechanisms of

Qualifications

• PhD or DVM in biology, toxicology, or related field.
• 7+ years in preclinical safety assessment.
• Regulatory submissions and interactions preferred.

Responsibilities

• Design and evaluate exploratory and GLP toxicology studies.
• Develop preclinical strategies and risk assessments.
• Collaborate across CMC, Regulatory, and Discovery Sciences.
• Lead investigations into mechanisms of toxicity and advise regulatory strategies.

Skills

Toxicology

GLP Experience

Safety Pharmacology

Regulatory Submissions

Education

PhD or DVM

Job description

Role:

Lead safety assessment of novel oligonucleotide therapeutics for rare diseases within Wave's Preclinical and Clinical Development Sciences team.

Responsibilities:

design and critically evaluate exploratory and GLP toxicology studies, develop preclinical strategies, collaborate across functions including CMC, Regulatory, and Discovery Sciences, and provide risk assessments for program teams. Lead investigations into mechanisms of toxicity and communicate impact on regulatory strategies.

Requirements:

PhD or DVM in biology, toxicology, or related field; 7+ years of preclinical safety assessment experience, preferably with regulatory submissions and interactions; expertise in safety pharmacology, investigative toxicology, and GLP compliance; experience with drugs targeting hepatic, renal, muscular, or CNS disorders.

Preferred:

board certification in toxicology.

HighValue:

focus on oligonucleotide modalities (RNAi, editing), therapeutic areas including rare diseases, and regulatory toxicology expertise.

WorkSetup:

based in Lexington, MA, with potential for travel.