Associate Director, Regulatory CMC

Regulatory Jobs; San Carlos (CA); Hybrid; USD 180,000 - 211,000; Full time

Job summary

Vaxcyte in San Carlos, CA is seeking a senior Regulatory CMC professional to lead multi-product global regulatory CMC strategies for investigational products and to manage preparation and filing of CMC submissions.

You will interact with Health Authorities for CMC topics, guide cross-functional teams, and ensure compliance with evolving global regulatory requirements across development programs.

Qualifications

• Bachelor’s degree in a scientific discipline and at least 10 years in vaccine/biotech regulatory CMC.
• Experience drafting BLA, post-approval variations, INDs/IMPDs is highly preferred.
• Experience with health authority meetings and cross-functional teams.
• Strong writing, communication, and ability to meet deadlines.

Responsibilities

• Lead preparation and review of global CMC sections and agency interactions.
• Interpret EMA/FDA/ICH regulations to ensure CMC compliance across teams.
• Define CMC data and documentation requirements for submissions.
• Provide CMC regulatory guidance to cross-functional teams and stakeholders.
• Manage regulatory assessments on product changes, deviations, and GMP investigations.
• Lead projects and serve as the primary regulatory CMC contact for assigned products.
• Represent the company in Health Authority meetings on CMC topics.
• Stay abreast of evolving regulatory CMC requirements and share knowledge.
• Contribute to department strategy and process improvements.

Skills

CMC regulatory knowledge

Regulatory strategy

Cross-functional leadership

Regulatory writing

FDA/EMA/ICH experience

GMP/CMC

Problem solving

Communication skills

Education

Bachelor’s degree in science

Tools

LIMS

SAP

TrackWise

Veeva

Job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHATwe do is every bit as important asHOWwe do it!Our work together is guided by four enduring core values:

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

A hands-on role providing both strategic and operational activities. This role develops and executes multi-product global regulatory CMC strategies for investigational products and leads the preparation and filing of regulatory CMC submissions. Manages interactions with Health Authorities for CMC topics. Provides regulatory CMC guidance to various cross-functional teams and ensures all applicable global regulatory requirements are considered and incorporated into product development. Conducts routine regulatory surveillance and communicates new/changing regulations.

Essential Functions:

• Leads the preparation and review of CMC sections of global regulatory submissions, as well as the interactions and responses with regulatory agencies
• Member of technical development teams which require experienced interpretation of applicable EMA/FDA/ICH/Global regulations to ensure CMC compliance
• Defines CMC content (data and documentation) requirements for regulatory submissions and compiles/reviews this content for conformance with established requirements
• Provides CMC regulatory guidance to cross-functional teams and key stakeholders
• Manages regulatory assessment and guidance on product compliance topics including change controls, deviations, and GMP investigations throughout development
• Leads projects with cross-functional teams and acts as the primary regulatory CMC contact for assigned products and projects
• Represents company in Health Authority meetings and leads or supports CMC preparation activities for meetings with Health Authorities on CMC related matters
• Stays abreast of current and evolving regulatory CMC requirements, applies this knowledge to assigned projects, and shares knowledge and experience with others to support their development
• Participates in the design, development and implementation of department strategies, providing recommendations in area of expertise

Requirements:

Bachelor’s Degree in a scientific discipline (e.g. Biology, Chemistry, Pharmacy, Regulatory Affairs for Drugs, Biologics or Medical Devices). Minimum 10 years of experience working in vaccine or biotech industry, or in a related field, or the equivalent combination of education and experience. Other combinations of education and/or experience may be considered.

• Prior experience preparing/authoring CMC DS sections:
• BLA highly preferred.
• Post-approval supplements/variations highly preferred.
• INDs/IMPDs.
• Prior development or manufacturing experience is a plus.
• Computer software skills (LIMS, SAP, TrackWise, Veeva will be used).
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency.
• Excellent interpersonal skills to communicate difficult concepts.

• Strategic thinking and strong problem-solving skills
• Collaborates and communicates in an open, clear, complete, timely, and consistent manner
• Strong sense of planning and prioritization, and the ability to work with all levels of management
• Advanced knowledge in regulatory (FDA, EMA, Health Canada and ICH) guidelines

Reports to:Executive Director, CMC Regulatory

Location:San Carlos, CA / US Remote

Work Arrangement: Remote

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $180,000 - $210,500 (SF Bay Area). Salary ranges for non-California locations may vary.

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We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.