Associate Director, In Vivo Toxicology — Hybrid/Remote

CRISPR Therapeutics; Boston (MA); Hybrid; USD 180,000 - 240,000; Full time

Job summary

CRISPR Therapeutics seeks an experienced toxicologist to advance IND-enabling pharmacology studies for in vivo programs. The role reports to the Director, Head of in vivo Toxicology and acts as a subject-matter-expert across toxicology, pharmacology, and DMPK to drive the nonclinical strategy forward.

The successful candidate will design and oversee non-clinical studies, ensure regulatory compliance, and collaborate with research, regulatory, and clinical teams to inform development and

Qualifications

• Ph.D. in toxicology or related field with 8+ years of relevant experience.
• Expertise in IND-enabling pharmacology, DMPK, and GLP toxicology studies.

Responsibilities

• Designs non-clinical non-GLP and GLP studies and protocols.
• Monitors and reviews study reports to support product development.
• Directs pharmacology, toxicology, and DMPK activities from in vivo studies to support FIH and beyond.
• Ensures studies meet FDA, CHMP, WHO, GLP, and ISO standards.
• Authors non-clinical sections for regulatory filings (IB, IND, CTA).
• Collaborates with cross-functional teams and senior leadership on project strategy.

Skills

Cross-functional collaboration

Regulatory writing awareness

Attention to detail

Excellent communication

Education

Ph.D. in toxicology or related field

Tools

CRO management

Job description

CRISPR Therapeutics seeks an experienced toxicologist to advance IND-enabling pharmacology studies for in vivo programs. The role reports to the Director, Head of in vivo Toxicology and acts as a subject-matter-expert across toxicology, pharmacology, and DMPK to drive the nonclinical strategy forward.

The successful candidate will design and oversee non-clinical studies, ensure regulatory compliance, and collaborate with research, regulatory, and clinical teams to inform development and