Associate Director, CMC Regulatory

lyellimmunopharma; Seattle (WA); On-site; USD 190,000 - 230,000; Full time

Benefits offered by this job

Equity Incentive Plan

Annual bonus eligibility

Job summary

Lyell Immunopharma in Seattle is seeking a senior CMC regulatory affairs professional to guide phase-appropriate regulatory strategies for cell therapy development. You will lead risk assessments, manage submissions, and partner across functions to ensure timely regulatory milestones.

The role requires 8+ years in CMC regulatory affairs, with experience from IND to marketing applications and a preference for global exposure.

Qualifications

• 8+ years of experience in CMC regulatory affairs.
• Experience leading CMC documentation and lifecycle management from IND to marketing applications.
• Global regulatory experience preferred but not required.

Responsibilities

• Provide phase-appropriate guidance related to CMC regulatory requirements for cell therapy development.
• Lead CMC regulatory risk assessments and identify mitigation activities throughout product lifecycle.
• Collaborate to develop CMC content for original INDs, IND amendments, IMPD for CTA and BLA/MAA submissions.
• Prepare CMC updates for regulatory documents including Investigator Brochures, Annual Reports, and pre-meeting packages.
• Coordinate and manage CMC regulatory projects and submission timelines with health authorities as required.
• Maintain knowledge of regulatory environment and opportunities/risks across lifecycle.
• Develop tools, templates, and best practices for CMC regulatory of cell & gene therapies.

Skills

CMC regulatory affairs

Regulatory risk assessment

IND/CTA/MAA preparation

Cross-functional collaboration

FDA/EMA/ICH knowledge

Leadership/management

Education

MSc or PhD in a scientific discipline

Job description

Using living cells to treat - and sometimes even cure - cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response. We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell's product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.

KEY ROLE AND RESPONSIBILITIES:

• Provide phase-appropriate guidance related to CMC regulatory requirements and expectations for cell therapy development
• Ensure timely escalation of critical issues to senior management by leading CMC regulatory risk assessment, identifying key CMC regulatory issues and mitigation activities needed throughout product life cycle
• Collaborate with CMC colleagues to develop CMC content for original INDs, IND amendments, investigational medicinal product dossiers (IMPD) for inclusion in Clinical Trial Applications (CTA) and BLA/MAA
• Participate in multidisciplinary efforts to prepare CMC updates for regulatory documents including Investigator Brochures, Annual Reports and premeeting meeting packages for Regulatory Authority meetings
• Coordinate, manage CMC regulatory projects including management of submission timelines, ensuring that CMC-related changes are reported in a timely manner to health authorities in accordance with regulatory requirements
• Maintain knowledge of the regulatory environment, regulations, and procedures. Identify CMC regulatory opportunity and risks across development lifecycle
• Partner with key stakeholders in developing tools, templates, and company-wide best practices for CMC regulatory of cell & gene therapies

PREFERRED EDUCATION:

• MSc or PhD within a scientific or related discipline

PREFERRED EXPERIENCE:

• A minimum of 8 years of experience in CMC regulatory affairs
• Experienced in leading CMC regulatory documentation and CMC lifecycle management from IND to marketing applications within the pharmaceutical or biotechnology industry
• Experience with cell therapy is desirable
• Global regulatory experience is preferred but not required
• Minimum 2 years management experience is preferred

KNOWLEDGE, SKILLS AND ABILITIES:

• Knowledge of FDA, EMA and ICH CMC regulations and guidelines for cell therapies
• Proven track record in preparing, reviewing and executing CMC regulatory documents to support clinical studies and marketing applications
• Strong oral and written communication skills
• Demonstrated ability to develop/maintain strong working relationships with the CMC team and cross-functional teams
• Ability to multi-task as needed in a fast-paced start-up environment
• Detail-oriented while also retaining the ability to see the big picture.
• Familiarity with AI-assisted tools for regulatory writing and document drafting (e.g., large language models), with sound judgment on appropriate use, human oversight, and QC of AI-generated content in submission-ready materials.

The salary range for this position is $190,000 to $230,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell's compensation practices and an applicant's qualifications and experience. Employees are also eligible to participate in Lyell's Equity Incentive Plan.

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be a