Analytical Development Research Scientist

Vertex Pharmaceuticals; Boston (MA); On-site; USD 103,000 - 154,000; Full time

Job summary

Vertex is seeking an Analytical Development Research Scientist to design and execute experiments for gene and cell therapy product characterization. The role blends advanced data analytics with hands-on assay development in a cross‑functional setting.

Responsibilities include developing analytical solutions, performing lab experiments, applying statistical analyses, and authoring SOPs and reports for regulatory filings. Strong communication and independence are essential.

Qualifications

• Ph.D. or equivalent with 0–3 years post-doctoral experience.
• Masters or equivalent with 3+ years relevant experience.
• Bachelors or equivalent with 6+ years relevant experience.

Responsibilities

• Independently conceptualize, develop analytical solutions for cell-based products.
• Perform lab experiments and apply statistics to assess specificity, linearity, precision and accuracy.
• Author and review SOPs, protocols, and technical reports; contribute to regulatory filings.
• Maintain accurate ELN/LIMS records and compliant documentation.
• Present findings to cross-functional teams and management.

Skills

Data science

Statistical analysis

Python

R

SQL

Education

Ph.D.

Masters degree

Bachelors degree

Tools

JMP

GraphPad Prism

Job description

Job DescriptionGeneral Summary:The Analytical Development Research Scientist works with a high degree of independence and is adept at designing and executing complex experimental procedures within required timelines. Completes work in a resourceful, self-sufficient manner and is able to troubleshoot and design alternative approaches to achieve desired outcomes. Performs strategic planning consistent with regulatory guidance, implements innovative approaches and maintains a high level of technical knowledge. Authors and reviews method documents, analytical study protocols and reports. Works collaboratively within the analytical development team and cross-functionally with other groups to meet CMC organizational goals. This is a hands-on role combining advanced data analytics with laboratory-based assay development in a cross-functional setting.Key Duties and Responsibilities:Independently conceptualize, develop, and deploy analytical solutions that support characterization of cell-based productsPerform laboratory experiments supporting analytical method development for gene and cell therapy products, and apply statistical analyses to assess specificity, sensitivity, linear range, precision, and accuracyAnalyze complex experimental and process data, and create clear visualizations and present findings and recommendations to technical teams and managementExecute test methods supporting Process Development activities to support process improvementsAuthor and review SOPs, protocols, technical reports, and transfer and qualification documentation, and contribute analytical content to regulatory filingsMaintain clear, accurate, and compliant records, including electronic lab notebooks and test formsStay current with developments in the broader data science community and apply relevant approaches to analytical challengesKnowledge and Skills:Demonstrated experience applying data science and statistical analysis to complex scientific questionsAbility to independently plan and execute technical work, interpret results, and communicate conclusions to cross-functional audiencesAdvanced data analysis, statistical analysis (e.g. JMP, GraphPad Prism, PLA analysis), data visualization, machine learning, and modeling proficiencyStrong skills in analytical programming (Python, R, SQL, cloud platforms)Hands-on experience with at least one of the following: cell count & viability, cell cluster characterization, flow cytometry, mammalian cell cultureAssay development, qualification, troubleshooting, optimization, and performance trendingCharacterization and release testing for identity, purity, strength, and potencyClear and effective communication abilitiesIndependent project leadershipEthical data practice adherenceExperience with ELN/LIMS systemsSOP, protocol, and technical report authoringKnowledge around regulatory guidance for cell therapy and cell-based assay development from FDA, ICH, and USPEducation and Experience:Ph.D. (or equivalent degree) and 0-3 years of relevant post-doctoral employment experience, orMasters Degree (or equivalent degree) and 3+ years of relevant employment experience, orBachelors Degree (or equivalent degree) and 6+ years of relevant employment experienceExperience in an analytical development program, providing technical support in a manufacturing setting or technical role in a QC environmentExperience designing and/or performing assay qualification, including authoring and/or reviewing relevant documentationAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.Pay Range:$102,800 - $154,200Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-OnsiteCompany InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]