AI Scientist/Senior, Clinical & Molecular Genomics Modeling, BRAID

Genentech; South San Francisco (CA); On-site; USD 128,000 - 274,000; Full time

Job summary

Genentech, a Roche company, is advancing Biological Research | AI Development (BRAID) within AI Biology & Translation. We seek a Scientist/Senior Scientist with strong computational and data-science foundations to develop AI methods that translate into biological and clinical impact.

You will define modeling applications for trial decision processes and partner with clinical teams to ensure models improve outcomes.

Qualifications

• Ph.D. in Computer Science, Bioinformatics, Computational Biology, or a related quantitative field.
• Proven experience building machine learning and AI models from scratch.
• Hands-on experience working with messy genomics data and/or clinical datasets.

Responsibilities

• Build New AI Models: Develop innovative models to enhance insights from outcome data and design interpretable ML frameworks.
• Connect Molecular and Clinical Data: Create models that link heterogeneous molecular data with clinical outcomes.
• Master the Data: Integrate messy, heterogeneous data from internal and public cohorts into a unified modeling framework.
• Influence Trial Design: Identify data collection requirements for future trial designs to ensure modeling success.
• Deploy and Educate: Share and deploy these models with clinical stakeholders to drive impact.

Skills

AI/ML Expertise

Biological Data Proficiency

Modern Engineering

Data Modeling

Education

Ph.D. in Computer Science, Bioinformatics, Computational Biology, or related field

Job description

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.

The Opportunity

Biological Research | AI Development (BRAID) is a team within AI Biology & Translation (AIBT) focused on developing state-of-the-art AI methods to solve key challenges in disease biology, target discovery, and translational research. We are seeking a Scientist/Senior Scientist with a strong foundation in computational, statistical, and data science, and a passion for translating technical advances into biological and clinical impact. You will develop and define the specifics of modeling applications that empower our clinical trials. This role requires a deep understanding of how a model can fit into Genentech’s drug development lifecycle—including identifying users, determining data availability timelines, and understanding how decisions are made. You will work alongside clinical and translational research colleagues to ensure models directly improve their decision-making processes.

In this role, you will:

• Build New AI Models: Develop innovative models to enhance insights from outcome data and design interpretable ML frameworks.


• Connect Molecular and Clinical Data: Create models that link heterogeneous molecular and cellular data with clinical outcomes, specifically focusing on prognostic, predictive, and pharmacodynamic biomarkers.


• Master the Data: Integrate messy, heterogeneous data from internal and public cohorts into a unified, generalizable modeling framework.


• Influence Trial Design: Identify necessary data collection requirements for future trial designs to ensure modeling success.


• Deploy and Educate: Share and deploy these models with other computational users and clinical stakeholders to drive impact.

Who you are

• Education: Ph.D. in Computer Science, Bioinformatics, Computational Biology, or a related quantitative field.


• AI/ML Expertise: Proven experience building machine learning and AI models from scratch.


• Biological Data Proficiency: Hands-on experience working with \"messy\" genomics data (e.g., aggregating dozens or hundreds of studies) and/or clinical datasets.


• Modern Engineering: Ability to effectively use agentic coding tools to improve the quality and quantity of code and modeling outputs.

For an AI Scientist

• Education: Ph.D. in Computer Science, Bioinformatics, Computational Biology, or a related quantitative field


• AI/ML Expertise: Proven experience building machine learning and AI models from scratch.


• Biological Data Proficiency: Hands-on experience working with \"messy\" genomics data (e.g., aggregating dozens or hundreds of studies) and/or clinical datasets.


• Modern Engineering: Ability to effectively use agentic coding tools to improve the quality and quantity of code and modeling outputs.

For a Senior AI Scientist

• Education: Ph.D. in Computer Science, Bioinformatics, Computational Biology, or a related quantitative field + 2 years of experience building ML models and/or interpreting models for target discovery, biomarker discovery, or clinical decision making


• AI/ML Expertise: Proven experience building machine learning and AI models from scratch. Expertise within an area of modern machine learning research, such as graph/diffusion/transformer models, reinforcement learning, or multimodal representation learning.


• Biological Data Proficiency: Hands-on experience working with \"messy\" genomics data (e.g., aggregating dozens or hundreds of studies) and/or clinical datasets.


• Modern Engineering: Ability to effectively use agentic coding tools to improve the quality and quantity of code and modeling outputs.

Relocation benefits are NOT available for this job posting.

The expected salary range for this position, based on the location of California, for the AI Scientist is $127,500 - 236,900, and for the Senior AI Scientist is $147,800 - $274,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

#ComputationCoE

#tech4lifeComputationalScience

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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