Advisor - Medical Physics

100 Eli Lilly and Company; Indianapolis (IN); Hybrid; CAD 216,000 - 348,000; Full time

Benefits offered by this job

401(k) program

Medical benefits

Paid time off

Job summary

Eli Lilly and Company seeks an Advisor – Medical Physicist to apply nuclear medical physics in the research and development of imaging and dosimetry for radiopharmaceuticals. The role spans discovery through late-phase clinical research, emphasizing preclinical to translational imaging and robust dosimetry capabilities to support clinical development.

The candidate will lead tool development, validation, QC workflows, and regulatory-aligned processes, collaborating with discovery, clinical

Qualifications

• Advanced degree in Medical Physics or related field with research experience.
• Expertise in SPECT image reconstruction and quantitative dosimetry.
• Experience with PET imaging and regulatory-compliant software.

Responsibilities

• Lead development and validation of in-house RLT analysis tools (reconstruction, dosimetry, calibration).
• Provide quantitative imaging to screen radioligands and guide candidate selection.
• Develop imaging/dosimetry methods for preclinical RPT studies and translational dosimetry.
• Own validation strategy and ensure regulatory-aligned QC workflows.

Skills

Medical Physics PhD

SPECT imaging

PET imaging

Dosimetry

Software development

GCP compliance

Education

PhD in Medical Physics

Tools

Imaging software

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

This role will support the application of nuclear medical physics in the research and development of imaging and therapeutic radiopharmaceuticals (RPT) in Oncology. The individual will work in a multidisciplinary environment and contribute from discovery through late-phase clinical research, with a strong emphasis on enabling preclinical and translational imaging and dosimetry capabilities that support clinical development. The Advisor – Medical Physicist will provide hands-on technical expertise in SPECT image reconstruction (required), dosimetry analysis, scanner calibration, tool development, validation, QC workflows, and site qualification. This role will support the development of internal RLT analysis capabilities spanning discovery through clinical applications, enabling robust, scalable, and regulatory-aligned imaging and dosimetry workflows.

Responsibilities

• Lead development and validation of in-house RLT analysis tools, including image reconstruction, activity modeling, dosimetry calculation, and calibration methods in partnership with both the Discovery and Clinical teams
• Provide quantitative imaging and dosimetry to screen and rank candidate radioligands, informing candidate selection in partnership with the Discovery team
• Develop and implement imaging and dosimetry methodologies for preclinical RPT studies, including quantitative imaging and dose estimation in animal models, and translational dosimetry to estimate human dosimetry
• Own validation strategy and execution for internally developed tools, ensuring reproducibility and alignment with clinical and regulatory expectations
• Lead scanner qualification and performance characterization for preclinical and clinical PET and SPECT imaging systems in partnership with both the Discovery and Clinical teams
• Develop QC workflows and ensure consistent application across imaging reconstruction, dosimetry, and calibration outputs
• Perform internal dosimetry analyses across preclinical and clinical datasets and provide QC review of analysis outputs
• Identify and resolve technical bottlenecks in reconstruction, imaging, dosimetry, and QC workflows
• Support translation of preclinical imaging and dosimetry methods into early-phase clinical workflows
• Support development of SOPs, imaging manuals, dosimetry documentation, and regulatory deliverables
• Contribute to preparation of datasets, tables, figures, and analysis outputs supporting regulatory submissions
• Interface with IT and software engineering teams to implement, deploy, and maintain validated analysis platforms
• Support site qualification, troubleshooting, and routine data processing across studies
• Collaborate with cross-functional teams, external vendors, CROs, and imaging partners
• Ensure adherence to GCP, SOPs, and quality standards

Basic Requirements

• Advanced degree (PhD) in Medical Physics, Nuclear Physics, Biomedical Engineering or related field
• Preferred: Expertise in SPECT image reconstruction and quantitative SPECT imaging
• Preferred: Experience with PET reconstruction and quantitative PET imaging
• Experience in radiopharmaceutical/internal dosimetry (organ level and/or voxel-based methods)
• Experience developing or validating scientific software or quantitative imaging workflows
• Strong understanding of nuclear imaging modalities (SPECT, PET, CT, MR)
• Ability to perform technical QC and communicate results to multidisciplinary teams

Preferred Requirements

• Experience in complex quantitative analyses and/or cross-modality image integration
• Experience in enabling or leading cross-functional clinical trial workflows and regulatory processes
• Experience with software (flexible, scalable, open-arch) implementations that support science investigation workflows (continuous integration, unit testing, publish-ready release)
• Strong knowledge of regulatory submissions, re-active monitoring and, if needed, the ability to implement quality and compliance models
• Experience working on large (gigabytes) datasets, Cloud-based services, or other big-data infrastructure/platforms
• Strong written and oral communication skills, in particular ability to present or produce documentation, guidelines, or SOPs

Work Environment

This position is Remote Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $151,500 - $244,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

#WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly