Advisor, Drug Product Process Development

Scorpion Therapeutics; Watertown (MA); On-site; USD 141,000 - 207,000; Full time

Benefits offered by this job

401(k)

Health/dental/vision

Life insurance

Time off/leave

Well-being benefits

Job summary

Scorpion Therapeutics in Watertown, MA, is seeking a scientist to design, execute, and scale-up lipid nanoparticle (LNP) drug product processes. You will drive platform science and translate formulation work into robust manufacturing.

The role requires hands-on formulation and process development in carrier-based systems, with experience in DLS, Cryo-EM, and surface chemistry, plus strong communication in a fast-paced, matrixed environment.

Qualifications

• PhD/MS/BS in chemical/biomedical engineering, pharmaceutical sciences, chemistry, biology or related field.
• Hands-on formulation and process development in carrier-based or complex drug product systems (LNPs, liposomes, emulsions, microspheres).
• Knowledge of fluid mixing dynamics, particle self-assembly, and surface chemistry; characterization methods (DLS, Ribogreen, Cryo-EM).
• Proven ability to independently design/execute experiments and identify knowledge gaps.

Responsibilities

• Design, execute, and oversee experiments for development and scale-up of LNP drug product processes.
• Independently drive LNP platform science; translate formulation science into robust, scalable manufacturing processes.

Skills

LNP formulation

Scale-up processes

Surface chemistry

DLS

Cryo-EM

Cross-functional collaboration

Education

PhD in Chemical Engineering or related

MS in Chemical/Biomedical Engineering

BS in related field

Tools

Ribogreen

TFF hollow fiber filtration

Job description

Responsibilities

• Design, execute, and oversee experiments for technical development and scale-up of lipid nanoparticle (LNP) drug product processes.
• Independently drive LNP platform science; identify knowledge gaps and translate formulation science into robust, scalable manufacturing processes.

Basic Requirements

• PhD, MS, or BS in chemical engineering, biomedical engineering, pharmaceutical sciences, chemistry, biology, or related field (PhD: 0–5 yrs; MS: 7+ yrs; BS: 10+ yrs).
• Hands‑on formulation and process development in carrier‑based or complex drug product systems (e.g., LNPs, liposomes, emulsions, microspheres, advanced delivery platforms).
• Working knowledge of fluid mixing dynamics, particle self‑assembly, and surface chemistry; characterization methods (e.g., DLS, Ribogreen, Cryo-EM).
• Track record of independently designing/executing experiments; proactively identify knowledge gaps and propose structured plans.

Additional Preferences

• Experience with filtration technologies (e.g., TFF hollow fibers, flat sheets, depth filtration).
• Experience in a matrixed CMC environment with cross‑functional collaboration (manufacturing, analytical development, formulation).
• Strong oral/written communication; present complex technical information to diverse audiences.
• Organized, collaborative; manage multiple priorities in a fast‑paced environment.

Physical Demands/Travel

• Lab environment; travel <5%.

Compensation/Benefits (if applicable)

• Pay: $141,000-$206,800; potential company bonus; comprehensive benefits including 401(k), health/dental/vision, life insurance, time off/leave, and well‑being benefits.