Advisor - Biochemist, Pandemic Preparedness

Lilly; San Diego (CA); Sur place; USD 141 000 - 231 000; Plein temps

Avantages offerts par ce poste

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Flexible benefits

Résumé du poste

Lilly’s BioTechnology Center in San Diego, CA is seeking a highly skilled Molecular and Cellular Biochemist to join BioTDR’s pandemic preparedness team. You will design and produce antigen constructs and reagents for AI-assisted antibody discovery, focusing initially on Ebola GP and expanding to other high-consequence pathogens.

The role requires a Ph.D. in a related field with post-graduate experience in virology and extensive protein biochemistry expertise, including expression, purification,

Qualifications

• Ph.D. in biochemistry, structural biology, virology, or related field plus a minimum of 2 years post-graduate experience in a virology-related field such as antiviral discovery.
• Strong core proficiency in all aspects of protein biochemistry, including expression & purification, biochemical and biophysical characterization, and their application to the production of conformationally relevant viral antigens.

Responsabilités

• Design and production of recombinant viral antigen constructs, including modified forms such as prefusion-stabilized, multimeric fusions, and cellular receptor-based reagents that are optimized for antibody discovery screening and structural biology
• Build and maintain a Pathogen readiness package for each prioritized high-consequence pathogen including documented expression constructs, validated binding reagents, and characterized neutralizing epitopes
• Enable and participate in the design, engineering, and characterization of multi-specific virus targeting antibodies
• Collaborate across geographies and disciplines to drive innovative solutions in antibody discovery and engineering

Connaissances

Protein biochemistry

Expression & purification

Biophysical characterization

Virology

Leadership

Formation

Ph.D. in biochemistry/structural biology/virology or related

Description du poste

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record for delivering novel biotherapeutic medicines to advance into clinical research in key areas of unmet medical need across a variety of therapeutic areas. We are seeking a highly skilled and motivated Molecular and Cellular Biochemist to join our research team. This role is part of a dedicated pandemic preparedness team within BioTDR, working in close partnership with Lilly's Infectious Disease organization and external partners to create and develop capabilities to enable future pandemic preparedness. The successful candidate will design and produce the antigen constructs and structural reagents that enable both de novo AI-based antibody design and patient-derived antibody discovery workflows — providing the foundational substrate for a rapid outbreak response capability. Initial focus will be on Ebola virus glycoprotein, with subsequent expansion across a prioritized panel of high-consequence pathogens. The position is located at the Lilly BioTechnology Center in San Diego, CA.

Key Responsibilities will be the design and implementation of capabilities to enable antibody discovery and engineering targeting infectious agents, including the utilization of protein engineering to enable the development of reagents and biochemical assays to support antiviral antibody discovery, and will include the following activities:

• Design and production of recombinant viral antigen constructs, including modified forms such as prefusion-stabilized, multimeric fusions, and cellular receptor-based reagents that are optimized for antibody discovery screening and structural biology
• Build and maintain a "pathogen readiness package" for each prioritized high-consequence pathogen including documented expression constructs, validated binding reagents, and characterized neutralizing epitopes — updated as new data emerges
• Enable and participate in the design, engineering, and characterization of multi-specific virus targeting antibodies
• Embrace and celebrate diversity by using a relevant and unique background and set of experiences to provide new ideas to deliver innovative solutions drugging novel targets.

Basic Qualifications

• Ph.D. in biochemistry, structural biology, virology, or related field plus a minimum of 2 years post-graduate experience (post-doctoral or industry) in a virology-related field such as antiviral discovery
• Strong core proficiency in all aspects of protein biochemistry, including expression & purification, biochemical and biophysical characterization, and their application to the production of conformationally relevant viral antigens

Additional Skills and Preferences

• Working knowledge of filovirus biology, especially Ebola GP-mediated entry - enabling rapid contribution to the initial Ebola focus of the pandemic preparedness program
• Familiarity with relevant structural biology tools, including their application to antigen design for infectious agents
• Experience in the biochemical characterization of antibodies that target infectious agents, including a familiarity with epitope characterization and structural biology applications
• Experience collaborating with internal and external partners across geographies and disciplines
• Strong communication (oral and written), organizational, and leadership skills are expected as evidenced by a robust publication record
• Prior experience in the discovery and characterization of antibodies, especially in the context of engineering multi-specific formats
• Experience in creating protein libraries for use in antibody escape mapping
• Ability to work productively and collaboratively in an interdisciplinary team environment, particularly with BioTDR’s broader antibody discovery scientists, and including prior experience in technology transfer to other partner organizations
• Ability to prioritize multiple activities and thrive in a setting that requires quick movement between scientific challenges and comfort with ambiguity.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$141,000 - $231,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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