Advisor, Bioanalytical Chemistry

BioSpace; Watertown (MA); Sur place; USD 168 000 - 268 000; Plein temps

Avantages offerts par ce poste

Company bonus

401(k)

Health, dental, vision benefits

Flexible spending accounts

Résumé du poste

Orna Therapeutics, Inc., a Lilly subsidiary in Watertown, MA, seeks an experienced scientist to lead LC-MS/MS bioanalytical method development for PK and biomarker analyses across drug programs.

Ph.D. in Analytical Chemistry or related field with 3+ years of industry experience; hands-on LC-MS/MS expertise; mentor junior scientists and collaborate with CROs. Competitive compensation and comprehensive benefits.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related field with 3+ years of industry experience.
• Hands-on expertise with LC-MS/MS instrumentation for quantitative protein/peptide bioanalysis.
• Understanding of PK assay development and regulatory bioanalytical guidance.

Responsabilités

• Design, develop, and qualify LC-MS/MS methods for protein/peptide biomarkers and PK analytes in biological matrices.
• Lead strategy for IA-LC-MS/MS or hybrid LBA-LC-MS approaches for large-molecule biomarker analyses.
• Oversee sample analysis campaigns and ensure data quality and regulatory compliance.
• Author/review method validation protocols and reports; liaise with CROs for method transfer.

Connaissances

LC-MS/MS

PK assay development

Regulatory bioanalysis

Large molecule bioanalysis

Formation

PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related

Outils

LC-MS/MS instrumentation

Description du poste

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address. With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our pioneering expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

We are seeking an experienced scientist with expertise in liquid chromatography-mass spectrometry (LC-MS/MS) to lead bioanalytical method development, validation, and sample analysis supporting pharmacokinetic (PK) and protein biomarker assessments across drug development programs. This role will contribute scientific and technical leadership to cross-functional teams supporting discovery studies, including biotherapeutics and novel modalities (e.g., LNP, RNA-based therapeutics).

Key Responsibilities

• Design, develop, and qualify LC-MS/MS methods for quantifying protein/peptide biomarkers and PK analytes in biological matrices (plasma, serum, tissue) in accordance with FDA/EMA Bioanalytical Method Validation (BMV) guidance
• Lead technical strategy for immunoaffinity-LC-MS/MS (IA-LC-MS/MS) or hybrid LBA-LC-MS approaches for large-molecule and biomarker analysis
• Oversee sample analysis campaigns supporting animal studies, including troubleshooting matrix effects, parallelism, and assay robustness issues
• Author and review method validation protocols, reports, and SOPs; ensure compliance with regulatory and quality standards
• Serve as scientific point of contact for CRO partners, overseeing method transfer, technical review, and data quality
• Collaborate with discovery teams to support study design and interpretation of bioanalytical data
• Present data and technical rationale in cross-functional settings
• Mentor junior scientists and contribute to department-level technical training and process improvement

Basic Qualifications

Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related scientific discipline with 3+ years of relevant industry experience

Additional Skills/Preferences

• Hands-on expertise with LC-MS/MS instrumentation (e.g., triple quadrupole, high-resolution MS) for quantitative protein/peptide bioanalysis
• Understanding of PK assay development principles and regulatory bioanalytical guidance (FDA 2018 BMV, EMA equivalents)
• Experience with large molecule/biotherapeutic bioanalysis (e.g., biomarker proteins, mAbs, fusion proteins, novel modalities)

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$168,000 - $268,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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