2027 Spring Post Doctoral Fellow Purification Process Development, Waltham, MA

Mass Digital Health; Waltham (MA); On-site; USD 84,000 - 113,000; Full time

Job summary

Sanofi is seeking a Post Doctoral Fellow in Purification Process Development in Waltham, MA. The role focuses on advancing AEX chromatography for full vector enrichment in AAV drug substance development, with significant ML/data-science collaboration across CMC and process modeling teams.

The candidate will analyze chromatography data, develop predictive models, and help drive digital transformation within the unit, mentored by leaders in a collaborative environment.

Qualifications

• Ph.D. requirement with strong publications
• U.S. work authorization without sponsorship at application time
• Enrollment in accredited program during the internship/co-op
• Relocation to Waltham, MA and 40 hrs/week commitment

Responsibilities

• Collect, clean, and analyze AEX chromatography data.
• Build and evaluate predictive ML models.
• Integrate models with chromatography system for real-time decisions.
• Collaborate with cross-functional teams and present findings.
• Draft technical reports and publications.

Skills

Data science

Machine learning

Python

R

AEX chromatography

Data analysis

Team collaboration

Education

PhD in chemical engineering

PhD in bioinformatics

PhD in cheminformatics

PhD in data science

Tools

Python

R

Job description

Job Title: 2027 Spring Post Doctoral Fellow Purification Process Development

• Grade: Post Doctoral
• Location: Waltham, MA
• Duration: 24 months

About the Job

Looking to launch your career at the cutting edge of healthcare? Join Sanofi for a chance to develop with mentoring and guidance from inspirational leaders while helping to make an impact on the lives of countless people worldwide. We are seeking a highly motivated Post Doctoral Fellow to join our Purification Process Development team.

The Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support the development of life-changing advanced gene therapy products, including recombinant Adeno-associated viral vectors (AAV) and non-viral gene therapy products. We are seeking a highly motivated and creative scientist to join the Purification Process Development team as a Postdoctoral Fellow. This position focuses on advancing the application of machine learning to facilitate anion exchange (AEX) chromatography for full vector enrichment in AAV drug substance process development. Additionally, the fellow will have significant opportunities to contribute to Sanofi's digital transformation by collaborating on projects with other CMC teams and global process modeling and data science teams.

This is an exciting opportunity to leverage the transformative power of data science in the CMC field, accelerating breakthroughs for patients. Join us and contribute to Sanofi's ambition to become the first pharmaceutical company powered by artificial intelligence at scale.

Ready to grow your skills while helping shape the future of healthcare? At Sanofi, you’ll be empowered to learn, ask questions, and bring your ideas to life – all while supported by inspiring mentors and collaborative teams.

About Sanofi
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Systematically collect, clean, and analyze AEX chromatography data to enable advanced data analysis.
• Build and evaluate predictive machine learning models.
• Integrate predictive machine learning models with the chromatography system to enable real-time decision-making.
• Collaborate with cross-functional teams and present scientific findings.
• Draft technical reports and external publications to summarize scientific findings.

About You

Basic Qualifications:

• Currently holding a Ph.D. in chemical engineering, bioinformatics, cheminformatics or data science with a strong track record of publications.
• Must be permanently authorized to work in the U.S. and not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually require future sponsorship for long term employment and do not meet the Internal requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship.
• Must be enrolled in an accredited college or university throughout the duration of the co-op/internship.
• Must be able to relocate to the office location and work 40hrs/week, Monday to Friday for the full duration of the co-op/internship.

Preferred Qualifications:

• Strong laboratory experience and technical expertise in chromatography.
• Knowledge and hands-on experience with machine learning methodologies.
• Proficiency in programming languages such as Python or R for data analysis and model building.
• Ability to work independently or with minimal supervision and collaborate in a highly matrixed environment.
• Be effective for both verbal and written communications.
• Highly motivated and can deliver results within defined time frame.
• Curious and bold in proposing creative experimental designs and ideas.
• Ability to work in Biosafety Level 2 (BSL-2) lab, follow safe lab procedures, and maintain good laboratory practices including detail-oriented laboratory notebook documentation.
• Understanding of manufacturing scale purification process to produce drug substance.
• Experience in mechanistic modeling and data-driven models in purification process development.
• Demonstrated ability to translate mathematical models into computer programs using programming languages, e.g. Python or similar.

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future focused team.
• Stretch your skills through apprenticeships, internships, graduate programs, and international experiences that grow with you.
• Learn from inspiring mentors and collaborative teams while contributing to real projects that shape the future of healthcare.
• Build your future with access to the latest tools, digital innovation, and continuous learning that keep you ahead of the curve.

Compensation

The salary range for this position is $98.000 yearly. All compensation will be determined commensurate with demonstrated experience.

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Pursue progress, discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

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US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.