Senior Research Fellow/Research Fellow (Medicine)

National University of Singapore; Singapore; On-site; SGD 70,000 - 90,000; Full time

Job summary

A leading academic institution in Singapore is seeking a full-time Senior Research Fellow for the Metabolic Liver Disease Lab. This role involves leading research projects on metabolic dysfunction-associated fatty liver disease and collaborating with multidisciplinary teams. The ideal candidate has a PhD and extensive relevant experience, particularly in molecular biology and cell culture techniques. Competitive compensation and opportunities for professional development are provided.

Qualifications

• Understanding of the molecular/cellular basis of MAFLD, obesity and T2D is desired.
• Experience with gene perturbation tools is a strong plus.
• Experience working with murine models is also a strong plus.

Responsibilities

• Assist PI in coordinating and leading multiple wet lab projects.
• Facilitate research team development and optimize assays related to metabolic diseases.
• Maintain accurate records and present findings to colleagues.

Skills

Molecular Biology skills (RNA/protein extraction, qPCR, western blotting, IF)

Experience in handling 2D and 3D cell cultures

Excellent writing, communication and presentation skills in English

Highly organized and skilled in working independently

Ability to oversee research directions

Education

PhD with 3 years relevant post-doctoral experience

Tools

CRISPR/Cas9

Gene perturbation tools (siRNA, shRNA)

Job description

Interested applicants are invited to apply directly at the NUS Career Portal

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Yong Loo Lin School of Medicine (NUS) is recruiting a full-time Senior Research Fellow/ Research Fellow (1 year contract, renewable).

Purpose of the post

The National University of Singapore invites applications for Senior Research Fellow/ Research Fellow for the Metabolic Liver Disease Lab in the Department of Medicine, Yong Loo Lin School of Medicine. This role explores functional genomic methods to understand better the molecular mechanisms of metabolic dysfunction‑associated fatty liver disease (MAFLD). The Post Doc Scientist will have the opportunity to collaborate with various teams across the School of Medicine, including pathologists, hepatologists, and data scientists. The candidate should demonstrate technical experimental excellence as well as the capacity to lead the research team regarding research projects aimed at producing clinically translational applications.

Responsibilities

• Assist PI in coordinating and leading multiple wet lab projects, proposing research directions and meeting key project milestones.
• Assist PI to facilitate research team development, optimization, and validation of in vitro mammalian cell based assays that are related to metabolic diseases (such as cell culture, RNA/protein extraction, qPCR, western blotting and other metabolic‑related assays).
• Perform other related duties, incidental to the work described herein (such as conduct data analysis, ensure the validity and reliability of data, maintain accurate and complete records of all findings, present findings to colleagues).
• Assist PI with writing for ethics/grant application.
• Assist PI with organizing and publishing findings in high impact academic journals of good reputation.

Qualifications

• A PhD with 3 years relevant post‑doctoral experience.
• Understanding of the molecular/cellular basis of MAFLD, obesity and T2D, e.g., lipid metabolism dysregulation, insulin resistance, inflammatory pathways is desired.
• Experience in handling 2D and 3D cell cultures such as hepatocytes, adipocytes or skeletal muscle cells is essential.
• Molecular Biology skills (RNA/protein extraction, qPCR, western blotting, IF) is essential.
• Cell line and clinical data multi‑omics familiarity (e.g., transcriptomics, proteomics analysis) is a strong plus.
• Experience with gene perturbation tools, such as siRNA, shRNA and CRISPR/Cas9 is a strong plus.
• Experience working with murine models is a strong plus.
• Excellent writing, communication and presentation skills in English.
• Highly organized and skill in working independently and creatively to solve experimental problems within time constraints.
• Ability to oversee research directions for multiple projects and work in a multidisciplinary team.

Applicants should send the following documents via the NUS Career Portal:

• Cover letter highlighting relevant experience and career goals
• Curriculum Vitae, containing details of three named referees
• A complete NUS Personal Data Consent for Job Applicants (the form is available at NUS Personal Data Consent for Job Applicants)