Senior/Laboratory Technologist

Singapore-MIT Alliance for Research and Technology Centre; Singapore; On-site; SGD 50,000 - 80,000; Full time

Job summary

A prominent research institution in Singapore is seeking a Senior Laboratory Technologist for a project on the pathobiology of tRNA modifications in cardiac development. The ideal candidate will design proteomics experiments and optimize workflows while using advanced mass spectrometry techniques. Key requirements include a degree in biochemistry and experience with proteomics. This role provides an opportunity to contribute to impactful scientific research.

Qualifications

• Experience in mass spectrometry-based proteomics and data analysis.
• Experience in sample preparation for proteomics analysis.
• Familiar with bioinformatics tools and databases.

Responsibilities

• Design and perform proteomics experiments.
• Develop and optimize sample preparation workflows.
• Perform operation and maintenance on mass spectrometers.
• Analyze data and ensure compliance with lab safety standards.

Skills

Mass spectrometry-based proteomics

Experimental design

Data analysis

Attention to detail

Collaboration

Education

BS or MS in biochemistry or analytical chemistry

Tools

Thermo nano liquid chromatography

Orbitrap mass spectrometer

Proteomics software

Job description

Project Overview

The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Laboratory Technologist / Laboratory Technologist for a project: “The pathobiology of tRNA modifications in cardiac development and diseased cell states”. This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome and proteome in cardiac cell development and disease states. The successful candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific research.

Key Responsibilities

This role will suit an individual passionate about cardio-biology and proteomics studies to understand molecular mechanisms of protein translation in heart development and disease.

• Design and perform proteomics experiments (eg, TMT, DIA, DDA)
• Develop and optimize sample preparation workflows
• Perform operation, maintenance and data acquisition on high-resolution mass spectrometers
• Analyze data using advanced pipelines and support biological interpretation.
• Ensure compliance with lab safety, QC standards, and data integrity policies
• Maintains highly organized sample and data tracking and reporting workflow

Requirements

• BS or MS in biochemistry, analytical chemistry or related field
• Experience in mass spectrometry-based proteomics and data analysis
• Experience in sample preparation for proteomics analysis
• Experience in operating Thermo nano liquid chromatography and Orbitrap mass spectrometer
• Familiar with proteomics software as well as other bioinformatics tools and databases
• Excellent attention to detail, organizational skills, and ability to maintain accurate and detailed records.
• Strong communication and the ability to collaborate effectively with cross-functional teams.

To apply, please visit our website at: https://portal.smart.mit.edu/careers/career-opportunities

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.