Scientist (WLW Lab), SIgN

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A leading research institution in Singapore is seeking a highly motivated Scientist to join their dynamic research team. The ideal candidate will have a Ph.D. in Immunology or related fields and experience with mouse models in autoimmune research. Responsibilities include designing in vivo experiments, isolating primary cells, and collaborating with multidisciplinary teams to develop foundational knowledge of immune responses. Excellent communication skills are required for this role, which is integral to contributing to regulatory applications and scientific publications.

Qualifications

• Strong background in autoimmune animal models and related disciplines.
• Demonstrated hands-on experience with mouse models.
• Excellent verbal and written communication skills.

Responsibilities

• Design and execute in vivo mouse experiments.
• Isolate primary cells from tissues and perform cell culture.
• Collaborate across multidisciplinary teams.

Skills

Mouse models

Cell culture

Molecular biology techniques

Biochemistry

Data analysis

Scientific communication

Education

Ph.D. in Immunology or related field

Job description

The WLW Lab is seeking a highly motivated and skilled Scientist to join our dynamic research team at A*STAR. The ideal candidate will have a strong background in autoimmune animal models, cell and molecular biology, or related disciplines, and will play a key role in a well‑funded research project aimed at developing basic foundational knowledge of adaptive immune responses in autoimmune disease.

Key Responsibilities

• Design and execute in vivo mouse experiments, including but not limited to animal handling, antigen administration and tissue harvesting.
• Isolate primary cells from mouse or human tissues, cell culture of primary mammalian cells.
• Engineer stable cell lines by designing, generating, and using lentivirus or other transduction modalities.
• Perform comprehensive cell analyses using:
• Molecular biology techniques, e.g., DNA/RNA extraction, PCR, qPCR, molecular cloning, and gene expression analysis.
• Bulk and single cell RNA sequencing
• Flow cytometry
• Serological assays e.g., ELISA
• Analyze and interpret data.
• Maintain thorough laboratory records.
• Prepare technical reports, presentations, and manuscripts that may eventually contribute to regulatory applications (e.g. IND) and peer reviewed publications.
• Collaborate across multidisciplinary teams, including scientific and translational partners.

Job Requirements

• Ph.D. in Immunology, Cell/Molecular Biology, Structural Biology, Biochemistry, or a related field.
• Demonstrated hands‑on experience with mouse models, including antigen dosing and tissue dissection, is required.
• Proficiency in primary cell isolation and culture, including from mouse or human tissues.
• Strong technical skills in biochemistry.
• Solid foundation in molecular biology and genetics, including construct design and cloning.
• Familiarity with single‑cell transcriptomics or related high‑dimensional platforms, animal models and/or immunological techniques is advantageous.
• Excellent verbal and written communication skills, including the ability to present scientific findings clearly and effectively.
• Proven ability to complete and communicate scientific projects, as evidenced by at least one peer‑reviewed (co‑)first authored publication.
• Highly organized, self‑motivated, and capable of working independently and in cross‑functional teams.
• Able to maintain detailed laboratory records to be used for potential regulatory filings.
• Comfortable with tight timelines and milestone‑gated projects.