Scientist, Targeted RNA Delivery & Bioconjugation

Planet Pharma; Singapore; Sur place; SGD 120 000 - 180 000; Plein temps

Avantages offerts par ce poste

Relocation package

Résumé du poste

Planet Pharma in Singapore is seeking a Scientist specialising in Bioconjugation & Targeted RNA Delivery, a hands-on, bench-focused role developing ligand-oligonucleotide conjugates for targeted RNA delivery beyond the liver, collaborating with chemistry, biology and pharmacology teams.

The successful candidate will design, synthesize, purify and characterize conjugates, contribute to IP and publications, and engage with CROs and cross-functional drug discovery programs, with relocation

Qualifications

• PhD in Chemistry, Chemical Biology, Organic or Medicinal Chemistry or closely related discipline required.
• Approximately 2–6 years of relevant industry experience in bioconjugation or targeted delivery.
• Experience applying bioconjugation chemistry to ligand-oligonucleotide conjugates, ADCs, PDCs or other targeted delivery platforms.
• Hands-on knowledge of conjugation approaches such as click chemistry, lysine/cysteine coupling, enzymatic ligation and/or stimuli-sensitive linker technologies.
• Strong practical experience with purification techniques (RP-HPLC, affinity, IEX, HIC, SEC, TFF).
• Experience with analytical characterisation (LC-MS, LC-HRMS, CE-SDS, DSC, HIC, NMR).
• Exposure to CRO management and cross-functional drug discovery programs.
• IP, publications or IND-related activity advantageous.

Responsabilités

• Design and execute bioconjugation strategies for ligand-oligonucleotide conjugates with optimised delivery profiles.
• Perform hands-on synthesis, purification and analytical characterisation of conjugated oligonucleotides.
• Develop and optimise conjugation chemistries and linker strategies for targeted delivery.
• Work cross-functionally with oligonucleotide chemists, biologists and pharmacologists to evaluate candidates in vitro and in vivo.
• Support identification and optimisation of conjugates with strong tissue and cell selectivity and functional delivery.
• Coordinate with external CROs and suppliers supporting ligand libraries, reagents and project activities.
• Maintain reproducibility and scientific documentation; contribute to IP and publications.
• Present findings internally and contribute to technical reports and project decisions.

Connaissances

Bioconjugation

RNA delivery

Synthesis

Purification

Analytical methods

Formation

PhD in Chemistry or related

Outils

RP-HPLC

LC-MS

NMR

LC-HRMS

SEC

IEX

HIC

DSC

TFF

Description du poste

Planet Pharma in Singapore is seeking a Scientist specialising in Bioconjugation & Targeted RNA Delivery, a hands-on, bench-focused role developing ligand-oligonucleotide conjugates for targeted RNA delivery beyond the liver, collaborating with chemistry, biology and pharmacology teams.

The successful candidate will design, synthesize, purify and characterize conjugates, contribute to IP and publications, and engage with CROs and cross-functional drug discovery programs, with relocation