Scientist I/II (Discovery Biology - Structure Biology), EDDC

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 70,000 - 100,000; Full time

Job summary

A leading research organization in Singapore is seeking a highly motivated scientist to join their Structural Biology team. The role involves driving protein production for biophysical characterization and structural biology in drug discovery programs. Candidates should have a Ph.D. or Master's in a relevant field, with strong experience in recombinant protein expression and purification, and a collaborative mindset. This position offers an opportunity to contribute to impactful research projects.

Qualifications

• 3 - 6 years of relevant experience in academic or industry.
• Proven expertise in recombinant protein expression and purification.
• Hands-on experience with biophysical characterization techniques.

Responsibilities

• Establish and execute recombinant protein expression workflows.
• Troubleshoot challenges and propose innovative solutions.
• Collaborate to optimize workflows for structural biology.

Skills

Scientific expertise in protein expression

Biophysical characterization

Problem-solving mindset

Collaboration

Education

Ph.D. or Master's degree in Biochemistry

Tools

Chromatography systems (e.g., ÄKTA)

Job description

We are seeking a highly motivated and technically skilled scientist to join our EDDC Structural Biology team. The successful candidate will play a key role in driving protein production to support biophysical characterization and structural biology efforts within drug discovery programs.

This position requires an independent, solution-oriented scientist who can contribute to research projects and cross-functional collaborations. Experience in biophysics and structural biology will be considered a strong advantage.

Key Responsibilities

• Establish and execute recombinant protein expression, purification, and characterization workflows for both soluble and membrane proteins using prokaryotic, eukaryotic, and cell-free systems.
• Apply your scientific expertise to troubleshoot challenges and propose innovative solutions that drive experimental success.
• Collaborate across teams to optimize workflows and scale up pipelines for structural biology and biophysical characterization.
• Play a central role in coordinating protein production activities, ensuring high standards in data integrity, reproducibility, and best practices.
• Produce high-quality protein samples to support biophysical assays and structure determination efforts.
• Contribute to a collaborative and knowledge-sharing culture across functional groups within EDDC.

Qualifications and Experience

• Ph.D. or Master's degree in Biochemistry, Structural Biology, Biophysics, Molecular Biology, or a related field, with 3 - 6 years of relevant experience in academic or industry settings.
• Proven expertise in recombinant protein expression and purification using E. coli, insect, or mammalian systems.
• Hands-on experience with chromatography systems (e.g., ÄKTA or equivalent).
• Demonstrated ability to independently plan experiments, analyze data, and deliver results under tight timelines.
• Experience with biophysical characterization techniques (e.g., MST, BLI, ITC, DSF) and structural biology methods is a strong advantage.

Skills and Attributes

• Strong foundation in protein engineering, including tagging strategies and construct design.
• Familiarity with high-throughput systems for protein expression and purification, including small-scale screening approaches.
• A proactive and adaptable mindset, with a collaborative spirit and a passion for solving complex scientific challenges.
• Ability to thrive in a fast-paced, multidisciplinary environment and contribute meaningfully to team goals.