Research Fellow [LKCMedicine]

Nanyang Technological University; Singapore; On-site; SGD 60,000 - 90,000; Full time

Job summary

Nanyang Technological University in Singapore invites applications for a Research Fellow to contribute to a high-impact project investigating how intracellular lipid regulation changes with different diets and how the endocrine pancreas is protected in obesity and metabolic disease. You will work with mouse models, human islets, and multi-omics approaches.

The role emphasizes lipid metabolism, autophagy/lipophagy, and diabetes pathophysiology, with opportunities to extend expertise, publish, and

Qualifications

• PhD in Life Sciences, Biomedical Sciences, or related field.
• At least 2-3 years of relevant experience in molecular biology, cell culture, imaging, or metabolic disease models.
• Strong technical proficiency in laboratory techniques such as immunoblotting, immunofluorescence microscopy, qPCR, and animal handling.
• Familiarity with regulatory standards, good laboratory practices and experience with IACUC protocols.
• Excellent written and oral communication skills, with demonstrated ability to draft scientific manuscripts and presentations.
• Strong organizational, motivational and self-driven skills, with a team-player attitude (Entry-level candidates with strong experimental skills and interest in metabolic disease research are welcome to apply).

Responsibilities

• Conduct various in vitro assays/experiments, including histology, western blotting, immunofluorescence microscopy, etc.
• Perform in vivo experiments, animal studies
• Computational biology to integrate results and generate list of perturbed pathways
• Contribute to research grant proposal applications, including literature review and preliminary data
• Contribute to research deliverables, such as manuscript writing, attending local and/or international conferences
• Mentor and supervision of undergraduate/PhD students and junior research staff
• Collaborate effectively with the research teams to achieve overall research goals and objectives

Skills

Molecular biology

Cell culture

Immunoblotting

Immunofluorescence

qPCR

Animal handling

Education

PhD in Life Sciences, Biomedical Sciences, or related field

Job description

The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School, which offers both undergraduate and graduate programmes, is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University, Singapore, in partnership with Imperial College London, LKCMedicine aims to be a model for innovative medical education and a centre for transformative research. The School’s primary clinical partner is the National Healthcare Group, a leader in public healthcare recognised for the quality of its medical expertise, facilities and teaching. The School is transitioning to an NTU medical school ahead of the 2028 successful conclusion of the NTU-Imperial partnership to set up a Joint Medical School. In August 2024, we welcomed our first intake of the NTU MBBS programme, that has been recently enhanced to include themes like precision medicine and Artificial Intelligence (AI) in healthcare, with an expanded scope in the medical humanities. Graduates from the five-year undergraduate medical degree programme will have a strong understanding of the scientific basis of medicine, with an emphasis on technology, data science and the humanities.

The Molecular and Cellular Dysfunction in Diabetes Laboratory, led by Associate Professor Yusuf Ali, combines in vitro systems biology, advanced imaging, in vivo models and multi-omics technologies to elucidate pathways critical to type 2 diabetes mellitus pathogenesis, with focus on pancreatic and immune function. The team is moving into molecular nutrition, harnessing the power of novel ingredients and prebiotics to mitigate the rise of persons living with diabetes. A laboratory under the Nutrition, Metabolism and Health programme, our work seeks for causality so that we can translate mechanistic insights into therapeutic strategies for mitigating type 2 diabetes and related metabolic conditions. For more details, please view: https://dr.ntu.edu.sg/cris/rp/rp00609

We are seeking a passionate and motivated Research Fellow to contribute to a high-impact project exploring how intracellular lipid regulation is altered under different diets and how the endocrine pancreas can be better protected under obesity and metabolically dysregulated conditions. As type 2 diabetes is also a condition of low grade chronic inflammation, expertise on studying how circulating immune cells interact with tissue-specific immune cells will be a plus. The project investigates molecular mechanisms underpinning cell stress and resilience, integrating in vitro and in vivo studies using genetically modified mouse models, human islets, and multi-omics approaches. This position is ideal for researchers with a strong interest in lipid metabolism, autophagy/lipophagy, and diabetes pathophysiology.

• Conduct various in vitro assays/experiments, including histology, western blotting, immunofluorescence microscopy, etc.
• Perform in vivo experiments, animal studies
• Computational biology to integrate results and generate list of perturbed pathways
• Contribute to research grant proposal applications, including literature review and preliminary data
• Contribute to research deliverables, such as manuscript writing, attending local and/or international conferences
• Mentor and supervision of undergraduate/PhD students and junior research staff
• Collaborate effectively with the research teams to achieve overall research goals and objectives

• PhD in Life Sciences, Biomedical Sciences, or related field
• At least 2-3 years of relevant experience in molecular biology, cell culture, imaging, or metabolic disease models
• Strong technical proficiency in laboratory techniques such as immunoblotting, immunofluorescence microscopy, qPCR, and animal handling
• Familiarity with regulatory standards, good laboratory practices and experience with IACUC protocols
• Excellent written and oral communication skills, with demonstrated ability to draft scientific manuscripts and presentations
• Strong organizational, motivational and self-driven skills, with a team-plater attitude (Entry-level candidates with strong experimental skills and interest in metabolic disease research are welcome to apply)

Hiring Institution: LKC A research-intensive public university, Nanyang Technological University, Singapore (NTU Singapore) has 33,000 undergraduate and postgraduate students in the Engineering, Business, Science, Humanities, Arts, & Social Sciences, and Graduate colleges. It also has a medical school, the Lee Kong Chian School of Medicine, established jointly with Imperial College London. NTU is also home to world-class autonomous institutes – the National Institute of Education, S Rajaratnam School of International Studies, Earth Observatory of Singapore, and Singapore Centre for Environmental Life Sciences Engineering – and various leading research centres such as the Nanyang Environment & Water Research Institute (NEWRI) and Energy Research Institute @ NTU (ERI@N). Ranked amongst the world’s top universities by QS, NTU has also been named the world’s top young university for the past seven years. The University’s main campus is frequently listed among the Top 15 most beautiful university campuses in the world and has 57 Green Mark-certified (equivalent to LEED-certified) buildings, of which 95% certified Green Mark Platinum. Apart from its main campus, NTU also has a campus in Novena, Singapore’s healthcare district. Under the NTU Smart Campus vision, the University harnesses the power of digital technology and tech-enabled solutions to support better learning and living experiences, the discovery of new knowledge, and the sustainability of resources. For more information, visit www.ntu.edu.sg About NIE About RSIS About LKCMedicine About NTUItive