Research Assistant (Production Radiochemist)

NATIONAL UNIVERSITY OF SINGAPORE; Singapore; On-site; SGD 20,000 - 60,000; Full time

Job summary

A leading university in Singapore is seeking a Research Assistant (Production Radiochemist) for the Clinical Imaging Research Centre. The role involves the production of radiopharmaceuticals in a GMP environment, as well as assisting in method development. Candidates should have a BSc in a relevant science discipline and experience in laboratory techniques. This position offers a two-year contract with competitive remuneration.

Qualifications

• Practical experience in general laboratory techniques like pipetting and pH measurement.
• Experience in pharmaceutical production under GMP is an advantage.
• Ability to perform first-line troubleshooting on automated modules.

Responsibilities

• Perform radiolabelling of peptides and small molecules using radionuclides.
• Prepare and review batch records and SOPs.
• Assist with maintenance of radiochemistry synthesis modules.

Skills

Analytical techniques

Problem-solving skills

Attention to detail

Education

BSc degree in Synthetic Organic/Inorganic/Medical Chemistry

Tools

Laboratory equipment

GMP compliance

Job description

Interested applicants are invited to apply directly at the NUS Career Portal

Your application will be processed only if you apply via NUS Career Portal

We regret that only shortlisted candidates will be notified.

Job Description

The National University of Singapore invites applications for Research Assistant (Production Radiochemist) in the Clinical Imaging Research Centre (CIRC), Yong Loo Lin School of Medicine. CIRC is a dedicated molecular imaging research centre. It is equipped with on-site capability for the preparation of PET radiopharmaceuticals in a state-of-the-art GMP-certified facility. CIRC is positioned to support both academic and commercially led clinical research programs, with dedicated clinical imaging facilities area advanced modalities of PET-CT and PET-MRI. For more details on what we do, do visit https://medicine.nus.edu.sg/circ/. Appointments will be made on a two-years contract basis with the possibility of extension.

Purpose of the post

The Production Radiochemist at Clinical Imaging Research Centre (CIRC) is responsible for the routine production of radiopharmaceuticals inside the Clean Room environment, in compliance with Good Manufacturing Practice (GMP). The Radiochemist will be assisting in the method development and validation of new radiopharmaceuticals, including the preparation of standard operating procedures (SOPs) and other quality documentation. With strong technical and analytical expertise, the Production Radiochemist helps maintain high operational uptime, ensures regulatory compliance, and upholds patient and product safety standards.

Main duties and responsibilities

1. Perform radiolabelling of peptides, antibodies, or small molecules using radionuclides such as Lu-177, Ga-68, F-18, etc.
2. Prepare and review batch records, lab notebooks, SOPs and other QC documents.
3. Assist with emergency maintenance/calibration of radiochemistry synthesis and dispensing modules (e.g., Scintomics, iPhase, Trasis).
4. Support deviation investigations, CAPAs, and change control implementations as needed.
5. Perform ad-hoc clean room activities, including cleaning of rooms, stock inventory and environmental monitoring.
6. Safe handling of radioactive materials including hazardous waste disposal.
7. Working flexible hours, shifts, or weekends based on production schedules and isotope half-lives.
8. Performing any other duties as assigned by the Head of Department in accordance with GMP and safety regulations.

Physical Demands and Work Environment

• Willing to work with radioactive materials
• Able to read, listen and understand technical direction and procedures
• Able to lift heavy loads (up to 14kg with both hands)

Qualifications

The applicant should:

1. Have a minimum of BSc degree in Synthetic Organic/ Inorganic/ Medical Chemistry or a related science discipline;
2. Practical experiences in general laboratory techniques, such as analytical balance operations, pipetting, pH measurement and reagents preparation.
3. Experiences in pharmaceutical production under Good Manufacturing Practice (GMP) is an added advantage.
4. Experiences in radiolabelling and purification techniques with short-lived radioisotopes (F-18, C-11, Ga-68) or Lu-177 is highly desirable.
5. Proven ability to work independently with minimum supervision as well as a constructive team player.
6. Require critical thinking and problem-solving skills
7. High attention to detail and commitment to data integrity.
8. Those with no experience but with relevant academic and skills will be considered for this position
9. Ability to perform first-line troubleshooting and minor repairs on automated modules (e.g., replacing tubing, valves, connectors, heaters).
10. Ability to read technical manuals, interpret wiring diagrams, and communicate effectively with engineers or vendors for equipment servicing.

Remuneration will be commensurate with the candidate’s qualifications and experience. Informal enquiries are welcome and should be made to Miss Emmalyn Chan Mei Mei at [e-mail].

Formal application: Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of three (3) referees to the NUS Career Portal.

We regret that only shortlisted candidates will be notified.