PhD Student: CAR-T Cell Production & Translational Research

Karolinska Institutet, doctoral positions; Stockholms kommun; On-site; SEK 360,000 - 500,000; Full time

Job summary

Karolinska Institutet invites applications for a Doctoral (PhD) student position in clinical cell manufacturing within the Nordin lab at BCM, Huddinge. You will develop a hospital-based CAR T cell production pipeline using non-viral, CRISPR-based knock-in methods, evaluate constructs, and align processes with GMP standards to enable future clinical testing.

The position includes supervision by Joel Nordin and three co-supervisors, participation in group meetings and seminars, and the aim to

Qualifications

• Biomedical Scientist degree or license required.
• Strong background in cell therapy and translational research.
• Experience with hospital-based production of ATMPs is advantageous.
• Excellent teamwork and communication skills.

Responsibilities

• Develop CAR T cell production pipeline for clinical environment.
• Optimize CAR constructs and knock-in sites.
• Perform in vitro functional evaluations.
• Ensure GMP compliance and scale processes.
• Engage in group meetings and supervision.

Skills

English proficiency

Hospital-based production

Clean room experience

Cell manipulation

CRISPR knock-in

CliniMACS Prodigy experience

Electroporation

Education

Biomedical Scientist degree or license

Tools

CliniMACS Prodigy

MaxCyte electroporation

CRISPR tools

Job description

Karolinska Institutet invites applications for a Doctoral (PhD) student position in clinical cell manufacturing within the Nordin lab at BCM, Huddinge. You will develop a hospital-based CAR T cell production pipeline using non-viral, CRISPR-based knock-in methods, evaluate constructs, and align processes with GMP standards to enable future clinical testing.

The position includes supervision by Joel Nordin and three co-supervisors, participation in group meetings and seminars, and the aim to