Clinical Pharmacometrician in CVRM (Associate Director)

AstraZeneca GmbH; Mölndals kommun; Sur place; SEK 662 325 - 993 487; Plein temps

Résumé du poste

AstraZeneca GmbH is seeking a Clinical Pharmacometrician at an Associate Director level in Gothenburg, Sweden. This role is integral to our Clinical Pharmacology and Quantitative Pharmacology team, focusing on drug development within cardiovascular, renal, and metabolism therapies.

The ideal candidate will possess a strong quantitative background, expertise in mathematical and statistical modeling, and proficiency with pharmacometric software. Join us in advancing healthcare by turning ideas into life-changing medicines.

Qualifications

• PhD in pharmacometrics or mathematical/statistical modeling.
• Strong skills in population modelling and statistics.
• Hands-on experience with pharmacometric software.

Responsabilités

• Apply Model Informed Drug Development (MIDD) in clinical programs.
• Support design and interpretation of clinical studies.
• Identify and drive MIDD opportunities in drug development.

Connaissances

Pharmacokinetics (PK) knowledge

Mathematical/statistical modeling

Simulation skills

Strong quantitative skills

Excellent communication skills

Formation

PhD in pharmacometrics or relevant area

Outils

NONMEM

R

Stan

Monolix

Phoenix

Description du poste

Do you have expertise and experience in PK, PKPD, mathematical/statistical modeling and simulation, and Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your knowledge in a company that is dedicated to following the science and turning ideas into life‑changing medicines? If so, this could be your next challenge!

We have an exciting opportunity for an engaged and diligent individual to join our Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca in the vibrant site of Gothenburg, Sweden, in the role of a Clinical Pharmacometrician at an Associate Director level. This global position will support large‑ and small‑molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism. Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a groundbreaking Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of Clinical Pharmacometricians and Clinical Pharmacology Leads. You will thrive in an environment that inspires innovation, encourages multidisciplinary team‑working and collaboration with academia, and rewards original scientific thinking.

What you will do

Working closely with clinical pharmacologists, physicians, statisticians and other scientists, you will apply Model Informed Drug Development (MIDD) to contribute to clinical programs, support the design and interpretation of clinical studies, and influence key decisions in early and late clinical development. The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us. In collaboration with clinical pharmacologists, you will represent CPQP in cross‑functional clinical project teams and be responsible for identifying and driving MIDD opportunities to accelerate and advise decision making. Based on your interest, skills and experience, you might also take on strategic planning and delivery of the clinical pharmacology strategy acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer‑reviewed journals.

Minimum requirements for the role

• PhD in pharmacometrics or mathematical/statistical modeling and simulation or other relevant area
• Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling)
• Strong technical knowledge and hands‑on skills in PK and PK/PD modeling and simulation including training and experience with pharmacometric and statistical software (NONMEM, R, Stan, Monolix, Phoenix)
• Knowledge in pharmacology and drug targets
• Excellent oral and written communication skills

Desirable requirements

• 4+ years of industry experience or equivalent in quantitative modelling and its application in drug development combined with ability to independently support clinical programs
• Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
• Early and late phase clinical development experience
• Understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
• Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacometrics/pharmacology
• Knowledge in Cardiovascular, Renal or Metabolism disease areas
• Familiarity with applications of artificial intelligence in drug development is a strong plus

Equal Employment Opportunity

We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.