Associate researcher in lung transplantation

Lund University; Lunds kommun; On-site; SEK 402,000 - 536,000; Full time

Job summary

Lund University’s Biomedical Centre (BMC) in Lund is seeking a post-doctoral researcher to advance clinically oriented lung transplantation research. The project focuses on reactivation of developmental signaling pathways, lung tissue repair, and regeneration, using in vitro, ex vivo, and in vivo approaches bridging preclinical and clinical medicine.

The successful candidate will design and carry out experiments, including CRISPR/Cas9 genome editing, cell isolation and characterization, and

Qualifications

• PhD or equivalent in biochemistry, bioengineering, or cell and molecular biology.
• Experience with CRISPR/Cas9 genome editing in primary cells, including mesenchymal cells.
• Strong translational research background in lung transplantation or related fields.
• Experience with standard cellular/molecular techniques: Western blot, ELISA, mass spectrometry, qPCR, immunohistochemistry, HPLC.
• Experience isolating, culturing, and differentiating primary cells.
• Ability to work independently and collaborate with others.
• Mentoring/supervising postdocs and students is advantageous.

Responsibilities

• Independently design, plan, and conduct research; manage data across the project.
• Employ advanced CRISPR/Cas9 genome editing and tissue processing; protocol development and optimization.
• Isolate cells from tissue and characterize primary and commercial cells; assess proliferation, migration, ICC.
• Prepare high-quality manuscripts for international peer-reviewed journals.
• Collaborate with internal and external team members; mentor postdocs and students.

Skills

CRISPR/Cas9 genome editing

Cell culture

Data analysis

Scientific writing

Mentoring/supervision

Education

PhD in biochemistry, bioengineering, or cell & molecular biology

Tools

Western blotting

ELISA

Mass spectrometry

qPCR

Immunohistochemistry

HPLC

Tissue processing

Job description

Description Of Workplace

The research is conducted at the Biomedical Centre (BMC) in Lund, near Skåne University Hospital. It is carried out within the Department of Clinical Sciences at Lund University, under the leadership of Associate professor Sandra Lindstedt. The focus lies on clinically oriented research concerning lung transplantation related research, post-transplant complications and lung regeneration.

We offer

Lund University is a governmental authority.

• special benefits
• generous holidays
• a favorable occupational pension

Read more on the university's website about being employed at Lund University, Work at Lund University

Work Description

The duties at the research unit primarily consist of laboratory-based research, with a particular focus on cell culture, cell isolation, and gene therapy.

The successful candidate will primarily work on a research project investigating the reactivation of developmental signaling pathways in lung disease, with a particular focus on lung tissue repair and regeneration. The research will employ a combination of in vitro, ex vivo, and in vivo approaches. The position has a strong translational focus, bridging experimental/preclinical research and clinical medicine, primarily within the fields of thoracic surgery and pulmonary medicine.

The Main Responsibilities Include

• Independently designing, planning, and conducting research within the project, as well as collecting, analyzing, interpreting, and managing data generated throughout the project.
• The project involves advanced CRISPR/Cas9 genome editing, including tissue processing, protocol development and optimization, troubleshooting, and subsequent analysis and quantification.
• The work will also involve the isolation of cells from tissue and the characterization of both primary and commercially available cells, including analyses of proliferation, migration, immunocytochemistry (ICC), and related cellular functions.
• The position also includes responsibility for preparing high-quality scientific manuscripts for publication in international peer-reviewed journals.
• The majority of the work will be conducted independently, while also involving close collaboration with both internal and external members of the research team and other collaborators.
• In addition, the position includes mentorship and supervision of postdoctoral researchers, PhD students, and Master's students.

Basis for assessment

This is a merit-based position primarily focused on research. The position is intended as an initial step in the academic career, and the selection will be based primarily on scientific merit and potential as a researcher. Particular emphasis will be placed on demonstrated scientific skills within the subject area.

For postdoctoral appointments, the following shall form the basis for assessment:

• Proven ability to develop and conduct high-quality research
• Teaching and pedagogical ability

Additional qualifications will be assessed based on the following requirements for the position:

• PhD degree (or equivalent) in biochemistry, bioengineering, or cell and molecular biology.
• Technical proficiency and scientific creativity in one or more of the following areas: lungtransplantation, large animal models, CRISPR and / or cell modification.
• Background in translational work, lung transplant and large animal models.
• Experience with standard cellular and molecular biology techniques, including Western blotting, ELISA, mass spectrometry, qPCR, immunohistochemistry, and HPLC.
• Experience in the isolation, culture, and differentiation of primary cells.
• Experience with CRISPR/Cas9 genome editing of primary cells, including mesenchymal cells.

The research project is interdisciplinary, therefore candidates with a broad competence profile spanning theses different areas are of special interest.

Meritorious Qualifications

• Ability to run and coordinate interdisciplinary collaborations.
• Good written and verbal communication skills.
• Ability to carry out independent and high-quality research as documented through peer-reviewed publications.
• Documented Experience in mentoring and/or supervision.
• Good knowledge of clinical and translational lung transplantation.
• Developed gen modified cells for large animal models in lung transplantation.
• Hands-on experience of handling samples from patients and large animals.
• We look for a candidate that is highly motivated, positive and independent.

Eligibility

Appointment to a post-doctoral position requires that the applicant has a PhD, or an international degree deemed equivalent to a PhD, within the subject of the position. This eligibility requirement needs to be met no later than the time when the employment decision is made. We will mainly consider candidates who have completed their PhD degree no more than three (3) years before the last date for applications. Under special circumstances, the doctoral degree can have been completed earlier. These circumstances refer to leave due to illness, parental leave, clinical work, positions of trust within trade union organizations or other similar circumstances.

Terms of employment

This is a full-time employment limited to 2 years. Preliminary start is the 1st of January 2027, or according to agreement. The period of employment is determined in accordance with the agreement “Avtal om tidsbegränsad anställning som postdoktor” (“Agreement on fixed-term employment as a post-doctoral researcher”) between SACO-S, OFR/S and SEKO, dated November 19, 2021.