Postdoc in Novel Synthetic Biology Strategies for Blood-Brain Barrier Research

Institut Quimic Sarria (IQS) – Universitat Ramon Llull

Organisation / Company Institut Quimic Sarria (IQS) – Universitat Ramon Llull Department Bioengineering Research Field Biological sciences Chemistry Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 31 May 2025 - 23 : 59 (Europe / Madrid) Type of Contract Other Type of Contract Extra Information The position is funded for 24 months. Job Status Full-time Hours Per Week 38,5 Offer Starting Date 1 Jun 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Applications are invited for a position of postdoctoral scientist to be spent at the Institut Químic of Sarrià (IQS) in Barcelona.

The focus of the project, funded by the US Department of Defense, is the generation of new polymer-coated adeno-associated viral vectors for gene replacement in Duchenne muscular dystrophy. Due to the nature of the project, we are looking to appoint a highly motivated and enthusiastic scientist with excellent skills in both polymer chemistry and molecular biology.

Expertise in aseptic cell culture is desirable, as well as knowledge in polymer synthesis and nanovector characterization. Experience in adeno-associated virus (AAV) vector production would be an advantage, as would in vivo expertise. Training will be provided for any unfamiliar techniques. You are expected to be a good communicator, able to work both independently and collaboratively with other members of the laboratory.

• PhD awarded or PhD thesis submitted
• Independent design, execution, interpretation and writing up of experimental research programmes.
• Initiative and innovation in the development of research objectives and new lines of investigation.
• Monitoring RCI-related deliverables and milestone achievements.
• Contribution to the production of RCI-related research reports and their publication.
• Working to deadlines under time pressures if required.
• Good interpersonal skills.
• Ability to work as part of a team.
• Exploratory, analytical & innovative thinking.
• Safety conscious.
• Ability to physically perform normal lab tasks.
• Ability to lift boxes, small items of equipment.
• Willing to travel abroad on business.

Specific Requirements

• Polymer synthesis based on PBAEs and / or zwitterionic polymers.
• Knowledge of polymer analytical techniques such as 1H-NMR, gel permeation chromatography, and mass spectroscopy.
• Knowledge of physicochemical characterization techniques such as Z-potential, PAGE, TEM and asymmetrical flow field flow fractionation (AF4).
• Quantitative and semiquantitative PCR.
• Experience in : Polymer chemistry and characterization, Duchenne & other muscular dystrophies, Adeno-associated virus gene therapy vectors, Antisense & nucleic acid modulator drug development, Previous work in the field of gene therapy, A Home office licence holder with experience of animal experimental procedures.

Research Field Biological sciencesChemistry Years of Research Experience 4 - 10

Additional Information

We offer a highly competitive rewards and benefits package including generous annual leave and training and development opportunities. The postis based at the IQS in Barcelona.

Eligibility criteria

Expertise in western blotting, immunocytochemistry, and aseptic cell culture is desirable, as well as knowledge in polymer synthesis and nanovector characterization. Experience in adeno-associated virus (AAV) vector production would be an advantage, as would in vivo expertise. Training will be provided for any unfamiliar techniques. You are expected to be a good communicator, able to work both independently and collaboratively with other members of the laboratory.

Selection process

The following documents should be added to the application :

• Motivation letter explaining why you would be a good candidate for this position and our team.

We will contact the selected candidates and invite them to the interview. They will be asked to prepare a short (10 minutes) presentation of their recent research.

Additional comments

We are an equal opportunity employer . We promote equality and inclusion. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, disability status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law. We strongly welcome applications from female candidates as they are currently under-represented at this level in this field of knowledge in our School.

We also promote scientific and technological knowledge, business transformation and societal progress . At IQS we look for professionals committed to both these values.

Number of offers available 1 Company / Institute Institut Quimic Sarria (IQS) – Universitat Ramon Llull Country Spain State / Province Barcelona City Barcelona Postal Code 08017 Street Via Augusta, 390 Geofield

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