Principal Clinical Scientist

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We are a clinical-stage biopharmaceutical company focused on advancing innovative treatments for complex neurological and psychiatric conditions. Our mission is to develop novel therapies that address unmet medical needs through cutting-edge scientific approaches.

We are seeking a Principal Clinical Scientist to drive the early-stage clinical portfolio and contribute to the design and execution of our clinical strategy.

Key Responsibilities

• Provide scientific and clinical expertise to identify and implement surrogate biomarkers and endpoints that demonstrate pharmacological activity in early-phase patient studies.
• Offer insights into preclinical models and pharmacodynamic measures translatable to humans, ensuring predictive value for clinical outcomes.
• Support the development and execution of clinical strategies for early-stage programs, including experimental medicine and Phase 1b/2 trials.
• Assist in evaluating and selecting traditional and novel clinical endpoints and biomarkers (e.g., biochemical, electrophysiological, molecular, imaging, or other relevant technologies) for use in experimental medicine frameworks.
• Collaborate with internal and external teams to prepare and submit regulatory documents (e.g., Investigator’s Brochure, IND, CTA).
• Contribute to drafting grant proposals and scientific publications alongside team members and external partners.
• Stay current on advancements in neuroscience, including scientific literature, clinical trials, competitive landscapes, and industry collaborations relevant to the company’s focus.

Qualifications and Skills

• Extensive knowledge of central nervous system disorders, with a PhD in Neuroscience, Neuropharmacology, or a related field, and/or an M.D. with experience in developing treatments for anxiety disorders, movement disorders, or other neuropsychiatric conditions.
• In-depth expertise in neuroscience or neuropharmacology, with at least 5 years of experience in the pharmaceutical or biotech industry, focusing on early-stage CNS drug development.
• Strong understanding of clinical pharmacology principles and regulatory requirements for designing and conducting successful early-phase clinical studies.
• Experience in planning, managing, and overseeing drug development projects and activities.
• Proven ability to thrive in cross-functional project teams, coordinating tasks under tight timelines and high workloads.
• Exceptional organizational, negotiation, and strategic-thinking abilities.
• Fluency in written and spoken English is essential.

Candidate Profile

We are looking for a highly motivated, resilient, and collaborative individual with a passion for solving complex challenges in novel drug development. If you thrive in a dynamic, fast-paced biotech environment, excel in multidisciplinary teams, and are driven to advance innovative therapies for neuropsychiatric disorders, we encourage you to apply.

Seniority level

• Seniority level

  Associate

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science, Health Care Provider, and Research

• Industries

  Pharmaceutical Manufacturing and Biotechnology Research

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