PhD in Neurobiology of Pain Research

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Two PhD positions are available from February 1, 2026, at the University of Bern, in Switzerland, at the Department of Physiology, under the supervision of Dr.Mario A. Acuña ( https://physiologie.unibe.ch/~acuna/)

Description

We are hiring two PhD candidates to investigate how physical activity modulates chronic pain through brain-body communication using mouse models. One project focuses on body-to-brain mechanisms, exploring how molecules released during exercise affect brain circuits involved in pain perception. The other examines brain-to-body mechanisms, studying how descending neural pathways from the brain adapt to exercise to regulate pain signals at the spinal level. Both projects employ advanced neurobiological techniques and aim to uncover novel, non-pharmacological strategies for pain relief.

Qualifications

We seek motivated candidates with an MSc in Neuroscience, Biology, Biomedical Sciences, or related fields, and a strong interest in neurobiology, pain research, and brain-body interactions. Experience with mouse models, in vivo calcium imaging or ex vivo electrophysiology, stereotaxic surgery, viral vectors, opto/chemogenetics, molecular biology, and advanced microscopy is highly desirable. Proficiency in Python and/or MATLAB and familiarity with Git systems are also expected.

Responsibilities and Duties

• Design and conduct experiments to investigate either:
• Body-to-brain communication (e.g., how exercise-derived molecules influence brain circuits), or
• Brain-to-body modulation (e.g., how descending pathways regulate pain after exercise)
• Work with animal models of chronic pain, including behavioral assessments and surgical procedures
• Perform neurophysiological techniques such as in vivo calcium imaging or ex vivo electrophysiology
• Apply viral vector delivery, opto/chemogenetics, and microscopy for circuit analysis
• Analyze complex datasets using Python or MATLAB; maintain code using version control (Git)
• Collaborate within an interdisciplinary team and contribute to lab meetings and joint publications
• Present research findings at national and international conferences
• Contribute to a rigorous and transparent scientific environment prioritizing integrity and reproducibility

What we offer

• A dynamic, collaborative, and supportive environment within a young research team
• Access to state-of-the-art technology and core facilities
• Participation in scientific conferences in Europe and overseas
• A chance to make meaningful contributions to pain research with clinical relevance

Applications

Please send a single PDF containing:

• A cover letter (include your research interests, relevant experience, and preferred position, if any)
• Your CV
• Contact details for at least two academic referees

to:

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