PhD student: Cancer associated fibroblast autophagy, metabolism and desmoplasia in colorectal cancer

Sei unter den ersten Bewerbenden.

Nur für registrierte Mitglieder

Bern

CHF 100’000 - 125’000

Sei unter den ersten Bewerbenden.

Vor 2 Tagen

Jobbeschreibung

PhD student: Cancer associated fibroblast autophagy, metabolism and desmoplasia in colorectal cancer

Institute of Tissue Medicine and Pathology (ITMP) is an institution of the University of Bern, Switzerland, with three major task areas: teaching, research, and diagnostic service. With around 190 employees, ITMP provides an attractive setting to conduct cutting‑edge translational research in direct collaboration with pathologists and oncologists treating patients.

We are excited to present a unique opportunity to join an interdisciplinary team (spatial biology and ECM: Hannah Williams, metabolism: Martin Sadowski, autophagy: Mario Tschan, supported by GI pathologists: Heather Dawson, Rina Mehmeti) to examine the role of cancer‑associated fibroblast autophagy for desmoplasia in colorectal cancer (CRC). Desmoplasia is a common feature of tumour biology and is defined by excessive deposition of extracellular matrix (ECM) components such as collagen. A prominent desmoplastic reaction has been associated with tumour aggressiveness and impaired drug delivery across several cancer types. Understanding the biology underpinning desmoplasia and thereby identifying novel therapeutic targets represents a relevant clinical challenge. Emerging evidence from breast cancer suggests a role for CAF autophagy and altered metabolism in the induction and maintenance of the desmoplastic reaction. Whether this applies to other cancer types such as CRC remains to be elucidated.

Responsibilities

The successful candidate will explore the role of CAF autophagy and altered metabolism on desmoplasia and tumour behaviour in CRC. The PhD project will involve a variety of in vitro methods across 2D and 3D mono‑ and co‑culture models using clinically relevant patient‑derived specimens. As part of our interdisciplinary team, you will receive comprehensive training from experts in autophagy, spatial biology and ECM, metabolism, spatial biology and clinical pathology.

Requirements

• Academic degree (MSc or equivalent) in life sciences or biomedical sciences acceptable for matriculation at a Swiss University (Bologna compatible).
• Previous technical experience with 2D cell culture models and routine cell and molecular biology techniques is essential.
• Proactive, collaborative, excellent communication skills and the initiative to work independently.
• Prior expertise in programming languages (R, Python) or bioinformatics is an advantage.
• Fluency in English is a prerequisite.
• Successful applicant will be enrolled in the Graduate School for Cellular and Biomedical Sciences, University of Bern (www.gcb.unibe.ch).

Application

Please send your CV including a list of publications and description of your professional experience, a short motivational letter with statement of your research interests, a list of 2 references (including contact information) and copies of University diploma transcripts with grades as a single PDF‑document by email to Cornelia Mileto (cornea.mileto@unibe.ch). We will continue to accept applications until a suitable candidate is found.

Duration of appointment: 3‑4 years

Start: January 2026 or by arrangement

Salary: According to Swiss National Science Foundation (www.snf.ch)