Global Pharmacovigilance Medical Director

Beeline Medicines; Boston; Remote; PHP 16,943,000 - 21,911,000; Full time

Benefits offered by this job

Discretionary annual bonus

Long-term incentive

Job summary

Beeline Medicines is seeking a Pharmacovigilance Medical Director to provide senior medical leadership across safety activities for the I&I pipeline, including the lupus program. You will partner with regulatory and clinical teams to ensure patient safety and strong benefit-risk governance throughout development and post-market activities.

Remote-work role with periodic travel to Beeline Medicines offices as needed; a discretionary annual bonus and long-term incentive may be available based on

Qualifications

• MD/DO degree required; board certification or eligibility in immunology, rheumatology, internal medicine, or relevant specialty strongly preferred.
• Minimum of 5 years combined clinical and pharmaceutical/biotech industry experience; 2–3 years pharmacovigilance or drug safety preferred.
• Demonstrated expertise as physician-of-record for pharmacovigilance programs including ICSR review, signal evaluation, and aggregate safety reporting.
• Extensive knowledge of global safety regulations including FDA, EU GVP modules, and ICH guidelines.

Responsibilities

• Provide medical leadership for safety surveillance and pharmacovigilance activities across the I&I portfolio.
• Lead medical review of safety data from trials, spontaneous reports, literature, and real-world sources.
• Direct development of benefit-risk framework for regulatory submissions and safety communications.
• Guide safety signal management, escalation procedures, and DSMB oversight with cross-functional teams.

Skills

MD/DO

PV leadership

ICH/GVP knowledge

Regulatory submissions

Cross-functional leadership

Education

MD/DO medical degree

Board cert in immunology or rheumatology

5+ years in clinical/pharma industry

Job description

About Beeline Medicines:

Beeline Medicines is a clinical-stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully.

Job Summary:

The Pharmacovigilance Medical Director is the senior medical authority within the company's drug safety function, responsible for providing expert medical and scientific leadership across all pharmacovigilance activities supporting the immunology and inflammation (I&I) pipeline, including the company's lead lupus program. This role serves as the primary physician voice for benefit-risk evaluation, signal assessment, and safety governance, ensuring that patient safety is upheld as the foundational principle of all clinical development and post-market activities. The Medical Director partners closely with the Head of Pharmacovigilance, Clinical Development, Regulatory Affairs, Medical Affairs, and external Health Authorities to provide medically sound, strategically aligned safety leadership at a critical stage of the company's growth.

Work Arrangement & Location:

Remote - This position is designated as remote; the incumbent will be expected to travel to Beeline Medicines’ offices on a periodic basis to support in-person collaboration, team engagement, and business operations. The frequency and scheduling of such visits will be determined at the company's discretion based on business need.

Essential Duties and Responsibilities:

• Serve as the senior medical expert and physician for safety science and pharmacovigilance activities, providing authoritative medical judgment on individual case safety reports (ICSRs), aggregate safety analyses, signal evaluations, and benefit-risk assessments across the I&I portfolio.
• Lead the medical review and clinical data interpretation of safety data arising from clinical trials, spontaneous reports, literature, and real-world sources, ensuring timely, accurate, and scientifically rigorous assessment of all pharmacovigilance data.
• Direct the development and continuous maintenance of the company's benefit-risk framework, providing medical leadership in benefit-risk evaluations for regulatory submissions, label updates, and Health Authority safety communications.
• Lead the discussion at the company's Safety surveillance governance, providing medical and strategic direction on safety signal management, escalation procedures, and corrective action planning.
• Oversee the medical content and scientific quality of all aggregate safety reports, and regulatory submission dossiers for safety content.
• Partner with Clinical Development on the medical oversight of Data Safety Monitoring Board (DSMB) activities, clinical trial safety monitoring plans, safety risk mitigation plans (e.g.stopping rules), and protocol-level safety sections for all active and planned studies.
• Provide expert medical input to Risk management plans and relevant regulatory documents through developmental cycle of the programs, and risk minimization measure design, execution, and effectiveness assessment.
• Provide medical leadership and scientific mentorship to the Pharmacovigilance team, including PV Scientists, and other functions (e.g. Medical Writers, and Operations personnel) establishing a culture of medical excellence and patient-first decision-making.
• Perform other duties and responsibilities as assigned

Qualifications:

• Medical degree (MD or DO) required; board certification or eligibility in immunology, rheumatology, internal medicine, or a relevant specialty experience in autoimmune disease is strongly preferred
• Minimum of 5 years of combined clinical and pharmaceutical/biotech industry experience, with at least 2-3 years of dedicated pharmacovigilance or drug safety experience preferred.
• Demonstrated expertise serving as a physician-of-record for pharmacovigilance programs, including ICSR medical review, signal evaluation, benefit-risk assessment, and aggregate safety reporting.
• Deep knowledge of global safety and pharmacovigilance regulations including FDA guidance, EU GVP Modules I–XVI and ICH guidelines
• Extensive experience providing medical leadership for safety surveillance plan, and benefit-risk assessment, and submissions for IND and NDA/BLA, as well as direct authorship or oversight of complex safety narratives for regulatory submissions.
• Proven experience engaging with global Health Authorities on pharmacovigilance topics, including regulatory meeting preparation, written responses to safety queries, and inspection support.
• Demonstrated ability to lead or participate in DSMB oversight, clinical trial safety monitoring, and safety governance committee activities at the sponsor level.
• Experience contributing to Risk Management Plans (RMPs) and REMS programs, including development of risk minimization measures and assessment of effectiveness.
• Demonstrated ability to lead, mentor, and develop cross-functional teams in a fast-paced, resource-constrained biotech or pharmaceutical environment; fosters a culture of accountability, inclusion, and continuous learning.
• Proven track record of influencing without authority across organizational boundaries, driving alignment among senior stakeholders, and building consensus on complex scientific or operational priorities.
• Exceptional written and verbal communication skills with demonstrated ability to translate complex scientific, regulatory, or operational content for diverse audiences, including executive leadership, clinical teams, and external partners.
• Skilled at preparing and delivering compelling presentations, briefing documents and regulatory responses, and strategic updates to cross‑functional leadership teams and board‑level stakeholders.

Salary Range:

The expected salary range for this position varies by location and will be communicated based on the country or region in which the selected candidate is hired. Actual pay will be determined based on experience, qualifications, location, and other job‑related factors permitted by applicable local law. A discretionary annual bonus and long‑term incentive award (e.g., equity) may be available based on individual and Company performance.

$266,000 - $344,000 USD

Benefits:

We offer a comprehensive benefits package tailored to the country and region in which you are hired, in compliance with local laws and practices. Benefits may include, but are not limited to:

• Competitive health and wellness coverage (structure and premiums vary by country)
• Paid time off, public holidays, and additional leave entitlements in accordance with local requirements
• Flexible work arrangements / hybrid schedule

Benefits vary by location and are subject to eligibility requirements, local regulations, and plan terms. Specific benefit details applicable to your country or region will be provided during the offer process.

Equal Employment Opportunity:

Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Reasonable Accommodation:

If you require a reasonable accommodation to participate in the application or interview process, please contact [e-mail] to request an accommodation. We are committed to providing equal access to all candidates.