PhD in Bio-based Plastics Degradation & Toxicology

Utrecht University; Utrecht; On-site; EUR 36,000 - 45,000; Full time

Job summary

Utrecht University seeks a PhD candidate to bridge analytical chemistry and toxicology, studying bio-based and degradable plastics, their degradation products, and potential human health effects. You will work across ISCC and IRAS, combining chemistry, materials science and toxicology to advance Safe and Sustainable by Design.

The project spans two institutes, involves advanced characterization and in vitro models, and aims to translate findings into design recommendations.

Qualifications

• Master’s degree in chemistry or closely related field.
• Experience in micro- and nanoplastic research, or in chemistry and toxicology during Bachelor’s or Master’s work.
• Analytical/materials chemistry techniques such as FT-IR micro-spectroscopy and Raman spectroscopy; in vitro toxicology.
• Independent, critical thinker with collaboration across disciplines.
• Strong written and spoken English for an international consortium.

Responsibilities

• Investigate plastic degradation by exposing pristine polymers to controlled conditions and assess changes in chemical composition and material integrity.
• Characterize degradation products including micro- and nanoplastics, dissolved compounds and leachates using multiple analytical techniques.
• Assess hazards using tiered in vitro testing, starting with cytotoxicity, oxidative stress, and endocrine activity screening.
• Study higher tier biological effects in human-relevant cell models focusing on uptake, barrier integrity, inflammation, and metabolism.
• Integrate chemical and toxicological findings to guide Safe and Sustainable by Design recommendations.

Skills

micro- and nanoplastic research

analytical chemistry

in vitro toxicology

interdisciplinary collaboration

Education

Master’s degree in chemistry or closely related field

Tools

FT-IR micro-spectroscopy

Raman spectroscopy

AFM

AFM-IR

Electron microscopy

Mass spectrometry

Job description

Utrecht University seeks a PhD candidate to bridge analytical chemistry and toxicology, studying bio-based and degradable plastics, their degradation products, and potential human health effects. You will work across ISCC and IRAS, combining chemistry, materials science and toxicology to advance Safe and Sustainable by Design.

The project spans two institutes, involves advanced characterization and in vitro models, and aims to translate findings into design recommendations.