PhD candidate 'Modulating the tumor microenvironment to enhance radiosensitivity'

Radboudumc; Nijmegen; On-site; EUR 32,000 - 42,000; Full time

Job summary

Radboudumc in Nijmegen invites applications for a PhD project focused on modulating the tumor microenvironment to enhance radiotherapy responses. The research integrates patient-derived models with in vivo tumor models to dissect how TME features drive resistance and to explore strategies targeting CAFs, hypoxia, senescence, and immune interactions.

The ROI lab combines imaging, molecular, cellular, and immunological approaches to translate mechanistic insights into novel therapies, within an

Qualifications

• An MSc degree in Biomedical Sciences, Biology, Cancer Biology, or a related field, or an equivalent degree.
• A strong interest in preclinical cancer research.
• Motivated to investigate biological mechanisms underlying treatment response.
• Curious, enthusiastic about experimental science, and enjoy working in an interdisciplinary research environment.
• Experience with molecular and cellular biology, tumor biology, radiobiology or immunology is an advantage.
• Experience with preclinical animal models is welcome, and candidates with an Article 9 certificate for working with experimental animals are encouraged to apply.
• This position requires a Certificate of Conduct (VOG).

Responsibilities

• Investigate how modulation of the tumor microenvironment can enhance radiotherapy response.
• Work with patient-derived models and in vivo tumor models to study TME characteristics and treatment resistance.
• Assess readouts such as DNA damage/repair and tumor growth to understand mechanisms.
• Collaborate within the ROI lab to translate mechanistic insights into potential therapeutic strategies.

Skills

Preclinical cancer research

Interdisciplinary collaboration

Motivated to investigate mechanisms

Education

MSc in Biomedical Sciences or related field

Tools

Animal models

Job description

Job description

The tumor microenvironment (TME) plays an important role in determining how tumors respond to radiotherapy. Features such as stromal composition, hypoxia, and cellular senescence can contribute to radioresistance and may therefore represent potential therapeutic targets.

In this PhD project, you will investigate how modulation of the TME can enhance the response to radiotherapy. The project will combine patient-derived models and in vivo tumor models to study how different TME characteristics contribute to treatment response and to explore potential strategies to target these mechanisms. A range of complementary preclinical approaches is used, including hypoxia modulation, targeting of senescent cells or cancer associated fibroblasts (CAFs), (image-guided) radiotherapy and immune checkpoint inhibition. Treatment response and underlying mechanisms will be assessed through readouts such as DNA damage and repair, tumor growth and characterization of the TME. The precise experimental approaches will be guided by the scientific findings and direction of the project.

Place of work

At the Radiotherapy & OncoImmunology (ROI) lab of the department of Radiation oncology, ~ 20 researchers aim at better understanding how tumor cells interact with the surrounding tumor microenvironment (TME), and how these interactions influence response to cancer treatment, with a particular focus on radiotherapy.

Research is centred around the complex interplay between tumor cells, cancer-associated fibroblasts (CAFs), immune cells and other components of the TME. We aim to identify and therapeutically target TME features that contribute to treatment resistance, and to develop strategies that enhance the efficacy of radiotherapy. Our work combines imaging, molecular, cellular and immunological approaches, ranging from mechanistic studies to preclinical in vivo models.

The ROI lab is located within the department of Radiation Oncology, allowing for frequent interaction between basic and translational research and clinical practice. This provides an excellent environment for translating mechanistic insights into novel therapeutic strategies.

Profile

Requirements

• An MSc degree in Biomedical Sciences, Biology, Cancer Biology, or a related field, or an equivalent degree,
• A strong interest in preclinical cancer research,
• Motivated to investigate biological mechanisms underlying treatment response,
• Curious, enthusiastic about experimental science, and enjoy working in an interdisciplinary research environment.

Experience with molecular and cellular biology, tumor biology, radiobiology or immunology is an advantage. Experience with preclinical animal models is welcome, and candidates holding an Article 9 certificate for working with experimental animals are especially encouraged to apply.

Good to know

• This position requires a Certificate of Conduct (VOG).