Analyst in vitro ADME endocrine disruption

Charles River Labs; 's-Hertogenbosch; On-site; EUR 40.000 - 60.000; Full time

Job summary

A leading contract research organization in 's-Hertogenbosch is seeking a Technician for in vitro ADME endocrine disruption studies. The successful candidate will conduct toxicology studies and work within a dynamic team. A relevant HBO education in biology or biochemistry is required, along with experience in cellular assays and communication skills in Dutch and English. The organization offers excellent work conditions and opportunities for ongoing training.

Benefits

Ongoing training and support

27.5 holidays and 2 collective days

Bicycle lease plan

Company fitness membership

Free fresh fruit every day

Qualifications

• Experience with ex-vivo tissues and various readouts (e.g. luminescence, fluorescence, absorbance).
• Understanding of Good Laboratory Principles (GLP) is a plus.

Responsibilities

• Perform a variety of in vitro cell-based toxicology studies related to endocrine disruption.
• Implement and validate new studies.

Skills

Cell culture/cellular assays

Biological systems

Communication in Dutch and English

Hands-on attitude

Improvising and troubleshooting

Education

Relevant HBO education (HLO)

Tools

Radioactive materials certification

Job description

For 75years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well‑being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Are you up for a new challenge? For our in vitro Metabolism Team in Den Bosch we have a challenging opportunity for a Analyst in vitro ADME endocrine disruption with a wide variety of tasks and responsibilities.

At Charles River Laboratories Den Bosch we are currently hiring an:

Analyst in vitro ADME endocrine disruption

Department

The Discovery & Environmental Sciences department consists of approximately 90 employees. Within this department, research is carried out into the safety of existing and new substances. Characteristic of the work is the great diversity of tests, test substances, customers and collaborations.

The section in vitro ADME (IVA)

The section in vitro ADME (IVA) is a young and dynamic section that investigates the Absorption, Distribution, Metabolism and Excretion of various compounds (e.g. new medicines, (agro-) chemicals and consumer products).

The team consists of 9 study directors and 13 technicians. Within the team there is an open and flexible culture and a pleasant and informal atmosphere, where everyone supports each other and where you are valued.

For our in vitro studies we make use of various non‑animal test systems including human skin tissue, cell cultures, microsomes and supporting analytical techniques (e.g radio‑HPLC/ LC‑MS/MS, qPCR). Due to the increasing workload we have an opportunity for a technician: in vitro ADME endocrine disruption.

About the opportunity

As a technician you work in a dynamic team under supervision of a Study Director.

You will mainly be responsible for the performance of a diversity of in vitro cell‑based toxicology studies related to endocrine disruption which will include performance of the assay, sample pre‑treatment and sample analysis. In addition, you are involved in the implementation and validation of new studies.

Your profile

• A relevant HBO education (e.g. HLO); with a focus on biology / biochemistry
• Experience and affinity with cell culture/cellular assays, biological systems and/or working with ex‑vivo tissues and different readouts (e.g. luminescence, fluorescence, absorbance)
• Certification to work with radioactive materials is a plus
• You have a hands‑on attitude and ‘out‑of‑the‑box’ mentality and enjoy improvising and troubleshooting
• You have a pro‑active, results‑oriented, enthusiastic, dynamic and flexible attitude
• You have good communication and presentation skills, both in Dutch and English
• Understanding of Good Laboratory Principles (GLP) is a pré

Our offer

Working at our organization means working in a dynamic international organization with a modern laboratory and a wide variety of equipment and techniques at your disposal.

In addition, we offer excellent primary and secondary working conditions including:

• Ongoing training and support;
• 27.5 holidays and 2 collective days per year;
• Possibility to purchase 10 additional holidays per year;
• Annual one‑off 8% holiday pay of your gross annual salary;
• Annual one‑off payment based on company results;
• Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card;
• Bicycle (lease) plan;
• Collective pension with a small own contribution of 2.9%;
• Company fitness membership;
• The opportunity to play sports with colleagues on our own sports field;
• The possibility of a consultation with our in‑house ergonomist;
• Free fresh fruit every day.

About Safety Assessment

Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state‑of‑the‑art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.

About Charles River

Charles River is an early‑stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non‑GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well‑being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years.

At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to fostering a sense of belonging and work daily in this direction.