Senior Director, DMPK Project Leader (remote)

Lilly; India; Remote; INR 18,079,000 - 29,002,000; Full time

Benefits offered by this job

Company bonus

Comprehensive benefits package

Job summary

Lilly seeks a Senior Director, DMPK Project Lead in the US to drive nonclinical PK/ADME and toxicokinetics across a cross-functional program team.

The role requires end-to-end DMPK leadership in discovery and development, including NDA submissions for small molecules and progression of CNS candidates. Travel may be involved as part of collaboration with discovery and development teams.

Qualifications

• Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field.
• Minimum of 10 years of industry experience in a biotech or pharmaceutical setting.
• Expert in DMPK sciences with knowledge of drug discovery and development processes.
• Demonstrated ability to work cross-functionally and communicate scientific findings clearly and effectively.

Responsibilities

• Lead the filing of NDAs for DMPK.
• Deliver high-quality DMPK input and data to projects within established timelines.
• Utilize knowledge of DMPK to support/influence compound profiling, project progression and project strategy.
• Proactively calculate PK and toxicokinetic parameters, estimate safety margins and report results and interpretations to project teams and internal governance bodies.
• Lead, coordinate, and engage with DMPK colleagues, clinical pharmacologists, and toxicologists in project related activities.
• Prepare clear presentations related to the above for internal governance bodies.

Skills

DMPK leadership

Regulatory submissions

Cross-functional communication

Education

Ph.D. in Pharmaceutical Sciences/Pharmacology

Tools

Phoenix WinNonlin

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work in 2026.

Description of Role

Senior Director, DMPK Project Leader ensures delivery of all DMPK related activities working collaboratively as part of a cross-functional program team. These include nonclinical PK experiments, in vitro ADME, biotransformation studies,bioanalyticaland toxicokinetic analysis. This role supports understanding pharmacokinetic, toxicokinetic, and ADME principles to enable progression of drug candidates across the portfolio.A qualified candidate will havepreviousexperience in PK modeling ideally for CNS drug candidates and a basic understanding of vital ADME properties for CNS drug candidate progression. Furthermore, a qualified candidate will have end-to-end experience in drug discovery and development including NDA submission; will be able to partner with both discovery and development teams to enable the identification of lead candidates withoptimalDMPK properties for progression into nonclinical development and the progression of lead candidates into clinical development.

Key Responsibilities

• Lead the filing of NDAs for DMPK
• Deliver high-quality DMPK input and data to projects within established timelines
• Utilize knowledge of DMPK to support/influence compound profiling, project progression and project strategy
• Proactively calculate PK and toxicokinetic parameters, estimate safety margins and report results and interpretations to project teams and internal governance bodies
• Lead, coordinate, and engage with DMPK colleagues, clinical pharmacologists, and toxicologists in project related activities
• Prepare clear presentations related to the above for internal governance bodies

Qualifications

• Ph.D. inPharmaceutical Sciences,Pharmacology or a related field
• Minimum of 10 years of industry experience in a biotech or pharmaceutical setting
• Expert in DMPK sciences with knowledge of drug discovery and development processes
• Strong analytical and problem-solving skills
• Experience in DMPK project leadership
• Previous work in the discovery and/or development of CNS drug candidates
• Experience with regulatory submissions including NDAs for small molecules
• Knowledge, experience, and proficiency in supporting GLP-compliant studies
• Good knowledge of all DMPK assays including the use of in silico tools for PK prediction
• Proficiency with Phoenix WinNonlinand other software for NCA and PK modelingin small molecule drug discovery and development
• Demonstrated ability to work cross-functionally and communicate scientific findings clearly and effectively
• Collaborative mindset and operates with a sense of urgency
• Strong, proactive communication skills

Work Location

The Senior Director, DMPK Project Lead role based in the US, with occasional travel.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$192,000 - $308,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.