Scientist, Downstream Processing

Raspa Pharma Pvt. Ltd.; Lucknow; On-site; INR 900,000 - 1,300,000; Full time

Job summary

Raspa Pharma Pvt. Ltd. in Lucknow invites applications for a hands-on downstream process scientist to lead purification development for biosimilars and small molecules. The role is predominantly laboratory-focused and reports to the CEO.

Ideal candidates hold a PhD or MSc in Bioprocess/Chemical Engineering with 0–1 year industrial experience, strong HPLC knowledge, and a track record in DoE, data analysis, and process scale-up.

Qualifications

• PhD or MSc in Bioprocess/Chemical Engineering with 0–1 year industrial experience.
• Experience in downstream processing of biosynthetic small molecules.
• Proficient with preparative HPLC and chromatography equipment.

Responsibilities

• Design and execute novel purification methods for small molecules.
• Use Design of Experiments to screen conditions and optimize processes.
• Coordinate process monitoring, data analysis, and troubleshooting.
• Lead process scale-up activities and document SOPs and batch records.
• Work in cross-functional teams in a fast-paced environment.

Skills

Downstream processing

Design of Experiments

HPLC experience

Troubleshooting

Cross-functional collaboration

Education

PhD in Bioprocess Engineering

Master’s in Chemical Engineering

Tools

Preparative HPLC

Chromatography equipment

Automation technologies

Job description

Raspa is a biopharmaceutical company that is committed to reducing the cost of treatment for patients with cancer and other severe diseases. Our diverse and inclusive team is amalgamating technological innovation and automation strategies to make healthcare more accessible, affordable, and sustainable.We are looking for a talented downstream process veteran with proven leadership skills to join our dynamic organization. Qualified individuals will play a leading role in downstream process development for small molecules, proteins, and biosimilars. This position is expected to be mainly hands on in the laboratory. The person will be reporting to the CEO.

You will:

• Design and execute the development of a novel purification method for the small molecules of interest
• Use Design of Experiment (DoE) to screen purification conditions and optimize the process
• Plan, coordinate and execute activities for process monitoring and process data analysis
• Perform independent data recording, analysis and troubleshooting and support generation of SOPs, raw material specifications, batch records, and reports
• Lead and implement process scale-up activities
• Conduct technical investigations and risk assessments related with processes and provide process expertise in the resolution of complex technical or operational problems
• Implement continuous process improvement aimed at providing robustness, capacity, and productivity
• Determine root-causes of process variation and identify process trends to increase efficiency

Our ideal candidate will have:

• PhD or Master’s degree in Bioprocess Engineering, Chemical Engineering, or related discipline with 0-1 years of relevant industrial experience
• A previous track record of handling downstream processing of biosynthetic small molecules
• Relevant work experience in handling of preparative HPLC and associated chromatography equipment
• Ability to solve complex engineering problems involving Heat transfer, Mass transfer & fluid mechanics
• Sound understanding of concepts around involving precipitation, crystallization and related polymorphism concepts
• Ability to think critically, demonstrate troubleshooting and problem-solving skills
• Self-motivation with a strong sense of ownership in areas of responsibility and willingness to accept temporary responsibilities outside of initial job description
• Ability to adapt to a fast-paced environment and able to adjust workload based upon changing priorities
• Ability to work and collaborate in cross functional teams such as research, development, and manufacturing in a fast pace and dynamic team setting
• A clear willingness to “roll up their sleeves” and dive into the details
• Zeal to develop new bioprocessing and information technologies to help advance manufacturing

Nice to have:

• Previous experience of working with flexible schedule necessary to support occasional problem-solving and troubleshooting during off-hours
• Knowledge of current process technology trends in the field
• Experience with automation technologies is desired

We look forward to hearing from you

We welcome diverse perspectives and people who think rigorously and aren't afraid to challenge assumptions.