Invitro ADME scientist

Syngene International; Bengaluru; On-site; INR 1,500,000 - 1,900,000; Full time

Job summary

Syngene International Ltd. seeks an experienced DMPK/ADME scientist to lead planning and execution of metabolic stability and CYP inhibition assays using human liver microsomes. The role covers transporter assays, culture work, and rigorous data quality with strong emphasis on safety and collaboration.

Applicants should have nine or more years in industrial DMPK/ADME, with expertise in Excel and GraphPad Prism, and a willingness to work in a fast-paced lab environment.

Qualifications

• Nine or more years of industrial DMPK/ADME experience.
• In-depth knowledge of in vitro ADME assays and troubleshooting.
• Strong understanding of enzyme kinetics.
• Proficiency in Excel and GraphPad Prism.
• Experience with automation is desirable.

Responsibilities

• Plan and conduct metabolic stability and CYPIC50 inhibition assays using human liver microsomes.
• Support transporter and permeation assays (Caco-2, LLC-PK1-MDR1, MDCK) in 24/96 well formats.
• Design and execute physio-chemical and protein binding assays with high-quality data generation.
• Time-manage across multiple ADME projects to meet timelines.
• Maintain contemporaneous lab records and ensure high housekeeping standards.
• Adhere to safety rules and ensure a safe workplace.
• Coordinate with BA-DMPK group to design in vitro CYP inhibition studies.

Skills

ADME assays

In vitro metabolism

Enzyme kinetics

CYP inhibition

Cell culture

Excel

GraphPad Prism

Leadership

Automation

Education

M Pharm in pharmaceutical science

M Sc in biological science

Tools

Microsoft Excel

GraphPad Prism

Job description

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose

• Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality
• Support Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well plate trans well assays using different matrices with highest quality
• Design and execute physio-chemical and protein binding assays, generation of high-quality data, reviewing and uploading data into data bases with additional QC checks
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job

Key Responsibilities:

• Extensive experience in planning metabolic stability, CYP inhibition assays , Cell culture activities and Metabolism studies
• Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shiftassay with human liver microsomes.
• Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.

Educational Qualification:

• A M Pharm. in any pharmaceutical science or M Sc. in biological science.

Technical/functional Skills:

• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable

Experience:

• A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research.

Behavioral Skills:

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.